Four New Triterpenoid Saponins from the Root of Ilex centrochinensis

被引：2
|
作者：
Yang, Hang [1 ]
Lu, Yan-Xia [1 ]
Shi, Yu [1 ]
Deng, Xue-Ying [1 ]
Yi, Ying-Tao [1 ]
Li, Lu-Jun [1 ,2 ,3 ]
Hu, Ze-Hua [4 ]
机构：
[1] Hubei Univ, Natl & Local Joint Engn Res Ctr High Throughput D, State Key Lab Biocatalysis & Enzyme Engn, Hubei Key Lab Biotechnol Tradit Chinese Med, Wuhan 430062, Peoples R China
[2] Gansu Herbal Med Planting Co Ltd, Lanzhou 730102, Peoples R China
[3] Shenzhen Inst Geriatr, Shenzhen 518020, Peoples R China
[4] Hubei Univ Nationalities, Med Sch, Enshi 445000, Peoples R China
来源：
CHEMISTRY & BIODIVERSITY | 2021年 / 18卷 / 11期
基金：
中国国家自然科学基金;
关键词：
Ilex centrochinensis; triterpenoid saponins; structural elucidation; anti-inflammatory activity; CHEMICAL-CONSTITUENTS; GLYCOSIDES; LEAVES; LEAF;
D O I：
10.1002/cbdv.202100343
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
One new siaresinolic acid saponin (1) and three new rotundic acid saponins (2-4) were isolated from the roots of Ilex centrochinensis. Their structures were confirmed by detailed analysis of standard spectroscopic data (IR, MS, 1D and 2D NMR). Compounds 1-4 exhibited anti-inflammatory activity by inhibiting nitric oxide production in a lipopolysaccharide-induced RAW264.7 cell inflammatory model. However, they showed no significant lipid-lowering activity against the production of triglycerides in the lipid-accumulation model of HepG2 cells induced by oleic acid.
引用
收藏
页数：9
相关论文
共 50 条
  • [21] Triterpenoid Saponins with Potential Cytotoxic Activities from the Root Bark of Ilex rotunda Thunb.
    Liu, Wei-Jie
    Peng, Yu-Yuan
    Chen, Hao
    Liu, Xian-Fang
    Liang, Jing-Yu
    Sun, Jian-Bo
    CHEMISTRY & BIODIVERSITY, 2017, 14 (02)
  • [22] Two New Triterpenoid Saponins from the Root of Platycodon grandiflorum
    Ma, Guoxu
    Guo, Wenjie
    Zhao, Lizi
    Zheng, Qingxia
    Sun, Zhaocui
    Wei, Jianhe
    Yang, Junshan
    Xu, Xudong
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2013, 61 (01) : 101 - 104
  • [23] Four new triterpenoid saponins from the roots of Bupleurum rigidum
    Sánchez-Contreras, S
    Díaz-Lanza, AM
    Bernabé, M
    JOURNAL OF NATURAL PRODUCTS, 2000, 63 (11): : 1479 - 1482
  • [24] Triterpenoid saponins from the leaves of Ilex triflora Bl.
    Nga, Tran Thi
    Diep, Trinh Thi
    VIETNAM JOURNAL OF CHEMISTRY, 2025, 63 (01) : 54 - 60
  • [25] Latifolosides I and J, two new triterpenoid saponins from the bark of Ilex latifolia
    Huang, J
    Wang, X
    Ogihara, Y
    Shimizu, N
    Takeda, T
    Akiyama, T
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2001, 49 (02) : 239 - 241
  • [26] Latifolosides K and L, two new triterpenoid saponins from the bark of Ilex latifolia
    Huang, J
    Wang, X
    Ogihara, Y
    Shimizu, N
    Akiyama, T
    Takeda, T
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2001, 49 (06) : 765 - 767
  • [27] Three New E-Secoursane Triterpenoid Saponins from the Leaves of Ilex dunniana
    Zhang, Yue
    Li, Lu-Jun
    Zhang, Peng
    Pi, Hui-Fang
    Ruan, Han-Li
    Wu, Ji-Zhou
    HELVETICA CHIMICA ACTA, 2011, 94 (12) : 2207 - 2214
  • [28] Four new triterpenoidal saponins from Ilex cornuta and their cytotoxic activities
    Liao, Li
    Zhou, Xi
    Liu, Yan-li
    Xu, Qiong-ming
    Li, Xiao-ran
    Yang, Shi-lin
    PHYTOCHEMISTRY LETTERS, 2013, 6 (03) : 429 - 434
  • [29] TRITERPENOID SAPONINS FROM THE ROOT OF SIDEROXYLON FOETIDISSIMUM
    NICOLAS, G
    OULADALI, A
    GUILLAUME, D
    LOBSTEIN, A
    WENIGER, B
    ANTON, R
    PHYTOCHEMISTRY, 1995, 38 (01) : 225 - 228
  • [30] Triterpenoid saponins from the root of Anemone tomentosa
    Yi Wang
    Wei Kang
    Liang-jian Hong
    Wen-li Hai
    Xiao-yang Wang
    Hai-feng Tang
    Xiang-rong Tian
    Journal of Natural Medicines, 2013, 67 : 70 - 77
12345