Four New Triterpenoid Saponins from the Root of Ilex centrochinensis

被引：2
|
作者：
Yang, Hang [1 ]
Lu, Yan-Xia [1 ]
Shi, Yu [1 ]
Deng, Xue-Ying [1 ]
Yi, Ying-Tao [1 ]
Li, Lu-Jun [1 ,2 ,3 ]
Hu, Ze-Hua [4 ]
机构：
[1] Hubei Univ, Natl & Local Joint Engn Res Ctr High Throughput D, State Key Lab Biocatalysis & Enzyme Engn, Hubei Key Lab Biotechnol Tradit Chinese Med, Wuhan 430062, Peoples R China
[2] Gansu Herbal Med Planting Co Ltd, Lanzhou 730102, Peoples R China
[3] Shenzhen Inst Geriatr, Shenzhen 518020, Peoples R China
[4] Hubei Univ Nationalities, Med Sch, Enshi 445000, Peoples R China
来源：
CHEMISTRY & BIODIVERSITY | 2021年 / 18卷 / 11期
基金：
中国国家自然科学基金;
关键词：
Ilex centrochinensis; triterpenoid saponins; structural elucidation; anti-inflammatory activity; CHEMICAL-CONSTITUENTS; GLYCOSIDES; LEAVES; LEAF;
D O I：
10.1002/cbdv.202100343
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
One new siaresinolic acid saponin (1) and three new rotundic acid saponins (2-4) were isolated from the roots of Ilex centrochinensis. Their structures were confirmed by detailed analysis of standard spectroscopic data (IR, MS, 1D and 2D NMR). Compounds 1-4 exhibited anti-inflammatory activity by inhibiting nitric oxide production in a lipopolysaccharide-induced RAW264.7 cell inflammatory model. However, they showed no significant lipid-lowering activity against the production of triglycerides in the lipid-accumulation model of HepG2 cells induced by oleic acid.
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页数：9
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