Synthesis and antimycobacterial activity of some N,N′-disubstituted isonicotinohydrazide derivatives

被引：8

作者：

Sinha, N ^{[1
]}

Jain, S

Tilekar, A

Upadhayaya, RS

Kishore, N

Sinha, RK

Arora, SK

机构：

[1] New Chem Entity Res, Med Chem, Lupin Res Pk 46-47A, Pune 411042, Maharashtra, India

[2] New Chem Entity Res, Div Microbiol, Pune 411042, Maharashtra, India

来源：

ARKIVOC | 2005年

关键词：

tuberculosis; antimycobacterial activity; isonicotinohydrazide derivatives; pyrazine-2-carbonyl substituent;

D O I：

10.3998/ark.5550190.0006.202

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new series of antimycobacterial agents 2a-j, 3a-d, 6b-f,j, and 7b,f was designed, synthesized and evaluated for antimycobacterial activity against different mycobacterium species i.e. M. tuberculosis, M. avium, and M. intracellulare in an agar dilution method. Some of these compounds (2e, 3a-d) were highly potent with in vitro activity against M. tuberculosis H(37)Rv and clinical isolates ( sensitive strains), equivalent to that of Isoniazid.

引用

页码：9 / 19

页数：11

共 20 条

[1] COLAUTTI A, 1971, CHIM INDUSTR-MILAN, V6, P367
[2] MYCOBACTERIAL DISEASE, IMMUNOSUPPRESSION, AND ACQUIRED IMMUNODEFICIENCY SYNDROME
COLLINS, FM
[J]. CLINICAL MICROBIOLOGY REVIEWS, 1989, 2 (04) : 360 - 377
[3] ANTIMYCOBACTERIAL ACTIVITY OF A SERIES OF PYRAZINOIC ACID-ESTERS
CYNAMON, MH
KLEMENS, SP
CHOU, TS
GIMI, RH
WELCH, JT
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (07) : 1212 - 1215
[4] DESAI NC, 1984, J INDIAN CHEM SOC, V61, P239
[5] Active tuberculosis in individuals infected with human immunodeficiency virus after isoniazid prophylaxis
Fitzgerald, DW
Morse, MM
Pape, JW
Johnson, WD
[J]. CLINICAL INFECTIOUS DISEASES, 2000, 31 (06) : 1495 - 1497
[6] Govindarajan R, 2003, INDIAN J HETEROCY CH, V12, P229
[7] Recent developments in epidemiology, treatment, and diagnosis of tuberculosis
Carol Dukes Hamilton
[J]. Current Infectious Disease Reports, 1999, 1 (1) : 80 - 88
[8] HAWKINS JE, 1991, MANUAL CLIN MICROBIO
[9] HEARN MJ, 2002, Patent No. 02043668
[10] KHAN SA, 2002, ORIENTAL J CHEM, V18, P163

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