Cross Talk between Gut Microbiota and Intestinal Mucosal Immunity in the Development of Ulcerative Colitis

被引：62

作者：

Zou, Junfeng ^{[1
]}

Liu, Chen ^{[1
]}

Jiang, Shu ^{[1
]}

Qian, Dawei ^{[1
]}

Duan, Jinao ^{[1
]}

机构：

[1] Nanjing Univ Chinese Med, Jiangsu Collaborat Innovat Ctr Chinese Med Resour, Nanjing, Peoples R China

来源：

INFECTION AND IMMUNITY | 2021年 / 89卷 / 09期

关键词：

gut microbiota; mucosal immunity; ulcerative colitis; INFLAMMATORY-BOWEL-DISEASE; INNATE LYMPHOID-CELLS; ENVIRONMENTAL RISK-FACTORS; REGULATORY T-CELLS; EPITHELIAL-CELLS; TRYPTOPHAN-METABOLISM; DENDRITIC CELLS; CROHNS-DISEASE; TRANSPLANTATION; BACTERIA;

D O I：

10.1128/IAI.00014-21

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ulcerative colitis (UC), a nonspecific inflammatory disease, is characterized by inflammation and mucosal damage in the colon, and its prevalence in the world is increasing. Nevertheless, the exact pathogenesis of UC is still unclear. Accumulating data have suggested that its pathogenesis is multifactorial, involving genetic predisposition, environmental factors, microbial dysbiosis, and dysregulated immune responses. Generally, UC is aroused by inappropriate immune activation based on the interaction of host and intestinal microbiota. The relationship between microbiota and host immune system in the pathogenesis of UC is complicated. However, increasing evidence indicates that the shift of microbiota composition can substantially influence intestinal immunity. In this review, we primarily focus on the delicate balance between microbiota and gut mucosal immunity during UC progression.

引用

页数：16

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