Synthesis and cytotoxic evaluation of novel indenoisoquinoline-substituted triazole hybrids

被引：11

作者：

Tham Pham Thi ^{[1
,2
]}

Thuy Giang Le Nhat ^{[1
]}

Thuong Ngo Hanh ^{[1
]}

Tan Luc Quang ^{[1
,3
]}

Chinh Pham The ^{[1
,4
]}

Tuyet Anh Dang Thi ^{[1
]}

Ha Thanh Nguyen ^{[1
]}

Thu Ha Nguyen ^{[1
]}

Phuong Hoang Thi ^{[1
]}

Tuyen Van Nguyen ^{[1
]}

机构：

[1] Vietnam Acad Sci & Technol, Inst Chem, 18 Hoang Quoc Viet, Hanoi, Vietnam

[2] Thuyloi Univ, 175 Tay Son, Hanoi, Vietnam

[3] Hanoi Pedag Univ 2, Phuc Yen Town, Vinh Phuc Provi, Vietnam

[4] Thainguyen Univ Sci, Tanthinh, Thainguyen, Vietnam

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2016年 / 26卷 / 15期

关键词：

Indenoisoquinolines; Triazole; AZT; Hybrids; Cytotoxic agents; TOPOISOMERASE-I INHIBITORS; PANCREATIC-CANCER CELLS; MYELOID-LEUKEMIA CELLS; BIOLOGICAL EVALUATION; ANTICANCER AGENTS; ANTIPROLIFERATIVE ACTIVITY; CLICK CHEMISTRY; NITRATED INDENOISOQUINOLINES; DERIVATIVES SYNTHESIS; SELECTIVE INHIBITORS;

D O I：

10.1016/j.bmcl.2016.05.092

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of various substituted triazole-indenoisoquinoline hybrids was performed based on a CuI-catalyzed 1,3-cycloaddition between propargyl-substituted derivatives and the azide-containing indenoisoquinoline. Besides, a variety of N-(alkyl) propargylindenoisoquinolines was used as substrates for the construction of triazole-indenoisoquinoline-AZT conjugated via a click chemistry-mediated coupling with 3'-azido-3'-deoxythymidine (AZT). Thus, twenty three new indenoisoquinoline-substituted triazole hybrids were successfully prepared and evaluated as cytotoxic agents, revealing an interesting anticancer activity of four triazole linker-indenoisoquinoline-AZT hybrids in KB and HepG2 cancer cell lines. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：3652 / 3657

页数：6

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