A Prospective Study of 18F-DCFPyL PSMA PET/CT Restaging in Recurrent Prostate Cancer following Primary External Beam Radiotherapy or Brachytherapy

被引：48

作者：

Liu, Wei ^{[1
,2
]}

Zukotynski, Katherine ^{[3
,4
]}

Emmett, Louise ^{[5
,6
]}

Chung, Hans T. ^{[7
,8
]}

Chung, Peter ^{[8
,9
]}

Wolfson, Robert ^{[10
,11
]}

Rachinsky, Irina ^{[2
,12
]}

Kapoor, Anil ^{[4
,13
]}

Metser, Ur ^{[11
,14
]}

Loblaw, Andrew ^{[7
,8
,15
]}

Morton, Gerard ^{[7
,8
]}

Sexton, Tracy ^{[1
,2
]}

Lock, Michael ^{[1
,2
]}

Helou, Joelle ^{[8
,9
]}

Berlin, Alejandro ^{[8
,9
]}

Boylan, Colm ^{[4
,16
]}

Archer, Susan ^{[1
,2
]}

Pond, Gregory R. ^{[17
]}

Bauman, Glenn ^{[1
,2
]}

机构：

[1] London Hlth Sci Ctr, Dept Oncol, Div Radiat Oncol, London, ON, Canada

[2] Western Univ, London, ON, Canada

[3] Hamilton Hlth Sci Ctr, Dept Radiol, Hamilton, ON, Canada

[4] McMaster Univ, Hamilton, ON, Canada

[5] St Vincents Hosp, Dept Nucl Med & Theranost, Sydney, NSW, Australia

[6] Univ New South Wales, Sydney, NSW, Australia

[7] Sunnybrook Hlth Sci Ctr, Odette Canc Ctr, Dept Radiat Oncol, Toronto, ON, Canada

[8] Univ Toronto, Dept Radiat Oncol, Toronto, ON, Canada

[9] Princess Margaret Canc Ctr, Radiat Med Program, Toronto, ON, Canada

[10] Sunnybrook Hlth Sci Ctr, Dept Med Imaging, Toronto, ON, Canada

[11] Univ Toronto, Toronto, ON, Canada

[12] London Hlth Sci Ctr, Div Nucl Med, London, ON, Canada

[13] Urol Canc Ctr Res & Innovat, Hamilton, ON, Canada

[14] Princess Margaret Canc Ctr, Dept Med Imaging, Toronto, ON, Canada

[15] Univ Toronto, Inst Hlth Care Policy & Evaluat, Toronto, ON, Canada

[16] St Josephs Healthcare, Dept Diagnost Imaging, Hamilton, ON, Canada

[17] McMaster Univ, Dept Oncol, Hamilton, ON, Canada

来源：

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 2020年 / 106卷 / 03期

关键词：

INTENSITY FOCUSED ULTRASOUND; DOSE-RATE BRACHYTHERAPY; SALVAGE RADICAL PROSTATECTOMY; QUALITY-OF-LIFE; METASTASIS-DIRECTED THERAPY; RADIATION-THERAPY; FUNCTIONAL OUTCOMES; LOCAL RECURRENCE; PHASE-II; FAILURE;

D O I：

10.1016/j.ijrobp.2019.11.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: Radio-recurrent prostate cancer is typically detected by a rising prostate-specific antigen and may reflect local or distant disease. Positron emission tomography (PET) radiotracers targeting prostate-specific membrane antigen, such as 18F-DCFPyL have shown promise in restaging men with recurrent disease postprostatectomy but are less well characterized in the setting of radio-recurrent disease. Methods and Materials: A prospective, multi-institutional study was conducted to evaluate the effect of 18F-DCFPyL PET/computed tomography (CT) when added to diagnostic imaging (DI; CT abdomen and pelvis, bone scan, multiparametric magnetic resonance imaging pelvis) for men with radio-recurrent prostate cancer. All men were imaged with DI and subsequently underwent 18F-DCFPyL PET/CT with local and central reads. Tie break reads were performed as required. Management questionnaires were completed after DI and again after 18F-DCFPyL PET/CT. Discordance in patterns of disease detected with 18F-DCFPyL PET/CT versus DI and changes in management were characterized. Results: Seventy-nine men completed the study. Most men had T1 disease (62%) and Gleason score <7 (95%). Median prostate-specific antigen at diagnosis was 7.4 ng/mL and at relapse was 4.8 ng/mL. DI detected isolated intraprostatic recurrence in 38 out of 79 men (48%), regional nodal recurrence in 9 out of 79 (11%), distant disease in 12 out of 79 (15%), and no disease in 26 out of 79 (33%). 18F-DCFPyL PET/CT detected isolated intraprostatic recurrence in 38 out of 79 men (48%), regional nodal recurrence in 21 out of 79 (27%), distant disease in 24 out of 79 (30%), and no disease in 10 out of 79 (13%). DI identified 8 out of 79 (10%) patients to have oligometastatic disease, compared with 21 out of 79 (27%) with 18F-DCFPyL PET/CT. 18F-DCFPyL PET/CT changed proposed management in 34 out of 79 (43%) patients. Conclusions: 18F-DCFPyL PET/CT identified extraprostatic disease in twice as many men with radio-recurrent prostate cancer compared with DI and detected a site of recurrence in 87% of men compared with 67% with DI. Furthermore, 18F-DCFPyL PET/CT identified potentially actionable disease (prostate only recurrence or oligometastatic disease) in 75% of men and changed proposed management in 43% of men. (C) 2019 Elsevier Inc. All rights reserved.

引用

页码：546 / 555

页数：10

共 65 条

[1] Salvage focal and salvage total cryoablation for locally recurrent prostate cancer after primary radiation therapy [J].

Abreu, Andre Luis de Castro ;

Bahn, Duke ;

Leslie, Scott ;

Shoji, Sunao ;

Silverman, Paul ;

Desai, Mihir M. ;

Gill, Inderbir S. ;

Ukimura, Osamu .

BJU INTERNATIONAL, 2013, 112 (03) :298-307

[2] Hemi salvage high-intensity focused ultrasound (HIFU) in unilateral radiorecurrent prostate cancer: a prospective two-centre study [J].

Baco, Eduard ;

Gelet, Albert ;

Crouzet, Sebastien ;

Rud, Erik ;

Rouviere, Olivier ;

Tonoli-Catez, Helene ;

Berge, Viktor ;

Chapelon, Jean-Yves ;

Eggesbo, Heidi B. .

BJU INTERNATIONAL, 2014, 114 (04) :532-540

[3] Temporal Trends and Predictors of Salvage Cancer Treatment After Failure Following Radical Prostatectomy or Radiation Therapy An Analysis From the CaPSURE Registry [J].

Cary, K. Clint ;

Paciorek, Alan ;

Fuldeore, Mahesh J. ;

Carroll, Peter R. ;

Cooperberg, Matthew R. .

CANCER, 2014, 120 (04) :507-512

[4] Randomized Trial of a Hypofractionated Radiation Regimen for the Treatment of Localized Prostate Cancer [J].

Catton, Charles N. ;

Lukka, Himu ;

Gu, Chu-Shu ;

Martin, Jarad M. ;

Supiot, Stephane ;

Chung, Peter W. M. ;

Bauman, Glenn S. ;

Bahary, Jean-Paul ;

Ahmed, Shahida ;

Cheung, Patrick ;

Tai, Keen Hun ;

Wu, Jackson S. ;

Parliament, Matthew B. ;

Tsakiridis, Theodoros ;

Corbett, Tom B. ;

Tang, Colin ;

Dayes, Ian S. ;

Warde, Padraig ;

Craig, Tim K. ;

Julian, Jim A. ;

Levine, Mark N. .

JOURNAL OF CLINICAL ONCOLOGY, 2017, 35 (17) :1884-+

[5] Cancer Control and Functional Outcomes of Salvage Radical Prostatectomy for Radiation-recurrent Prostate Cancer: A Systematic Review of the Literature [J].

Chade, Daher C. ;

Eastham, James ;

Graefen, Markus ;

Hu, Jim C. ;

Karnes, R. Jeffrey ;

Klotz, Laurence ;

Montorsi, Francesco ;

van Poppel, Hendrik ;

Scardino, Peter T. ;

Shariat, Shahrokh F. .

EUROPEAN UROLOGY, 2012, 61 (05) :961-971

[6] A Prospective Phase 2 Trial of Transperineal Ultrasound-Guided Brachytherapy for Locally Recurrent Prostate Cancer After External Beam Radiation Therapy (NRG Oncology/RTOG-0526) [J].

Crook, Juanita M. ;

Zhang, Peixin ;

Pisansky, Thomas M. ;

Trabulsi, Edouard J. ;

Amin, Mahul B. ;

Bice, William ;

Morton, Gerard ;

Pervez, Nadeem ;

Vigneault, Eric ;

Catton, Charles ;

Michalski, Jeff ;

Roach, Mack, III ;

Beyer, David ;

Jani, Ashesh ;

Horwitz, Eric ;

Donavanik, Viroon ;

Sandler, Howard .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2019, 103 (02) :335-343

[7] Intermittent Androgen Suppression for Rising PSA Level after Radiotherapy [J].

Crook, Juanita M. ;

O'Callaghan, Christopher J. ;

Duncan, Graeme ;

Dearnaley, David P. ;

Higano, Celestia S. ;

Horwitz, Eric M. ;

Frymire, Eliot ;

Malone, Shawn ;

Chin, Joseph ;

Nabid, Abdenour ;

Warde, Padraig ;

Corbett, Thomas ;

Angyalfi, Steve ;

Goldenberg, S. Larry ;

Gospodarowicz, Mary K. ;

Saad, Fred ;

Logue, John P. ;

Hall, Emma ;

Schellhammer, Paul F. ;

Ding, Keyue ;

Klotz, Laurence .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (10) :895-903

[8] Salvage high-intensity focused ultrasound (HIFU) for locally recurrent prostate cancer after failed radiation therapy: Multi-institutional analysis of 418 patients [J].

Crouzet, Sebastien ;

Blana, Andreas ;

Murat, Francois J. ;

Pasticier, Gilles ;

Brown, Stephen C. W. ;

Conti, Giario N. ;

Ganzer, Roman ;

Chapet, Olivier ;

Gelet, Albert ;

Chaussy, Christian G. ;

Robertson, Cary N. ;

Thuroff, Stefan ;

Ward, John F. .

BJU INTERNATIONAL, 2017, 119 (06) :896-904

[9] A Systematic Review on the Role of Imaging in Early Recurrent Prostate Cancer [J].

De Visschere, Pieter J. L. ;

Standaert, Chloe ;

Futterer, Jurgen J. ;

Villeirs, Geert M. ;

Panebianco, Valeria ;

Walz, Jochen ;

Maurer, Tobias ;

Hadaschik, Boris A. ;

Lecouvet, Frederic E. ;

Giannarini, Gianluca ;

Fanti, Stefano .

EUROPEAN UROLOGY ONCOLOGY, 2019, 2 (01) :47-76

[10] Conventional versus hypofractionated high-dose intensity-modulated radiotherapy for prostate cancer: 5-year outcomes of the randomised, non-inferiority, phase 3 CHHiP trial [J].

Dearnaley, David ;

Syndikus, Isabel ;

Mossop, Helen ;

Khoo, Vincent ;

Birtle, Alison ;

Bloomfield, David ;

Graham, John ;

Kirkbride, Peter ;

Logue, John ;

Malik, Zafar ;

Money-Kyrle, Julian ;

O'Sullivan, Joe M. ;

Panades, Miguel ;

Parker, Chris ;

Patterson, Helen ;

Scrase, Christopher ;

Staffurth, John ;

Stockdale, Andrew ;

Tremlett, Jean ;

Bidmead, Margaret ;

Mayles, Helen ;

Naismith, Olivia ;

South, Chris ;

Gao, Annie ;

Cruickshank, Clare ;

Hassan, Shama ;

Pugh, Julia ;

Griffin, Clare ;

Hall, Emma .

LANCET ONCOLOGY, 2016, 17 (08) :1047-1060

← 1 2 3 4 5 6 7 →