Lack of association of Toll-like receptor 2 Arg753Gln with cutaneous leishmaniasis

被引：8

作者：

Ajdary, Soheila ^{[1
]}

Ghamilouie, Mir-Mostafa ^{[2
]}

Alimohammadian, Mohammad Hossein ^{[1
]}

Hosseini, Mansoureh ^{[1
]}

Pakzad, Saeed-Reza ^{[3
,4
]}

机构：

[1] Pasteur Inst Iran, Dept Immunol, Tehran 13164, Iran

[2] Azad Univ, Dept Biol, Basic Sci Fac, Res & Sci branch, Tehran, Iran

[3] Minist Hlth & Med Educ, Food & Drug Control Lab, Tehran 1113615911, Iran

[4] Minist Hlth & Med Educ, Res Ctr, Tehran 1113615911, Iran

来源：

PARASITOLOGY INTERNATIONAL | 2010年 / 59卷 / 03期

关键词：

Leishmaniasis; TLR; Polymorphism; LEPROMATOUS LEPROSY; CUTTING EDGE; POLYMORPHISM; INFECTION; GENE; MICE; TLR2; TOLL-LIKE-RECEPTOR-2; RESISTANCE; DISEASE;

D O I：

10.1016/j.parint.2010.03.008

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The aim of the present study was to investigate the frequency of Arg753Gln and Arg677Trp polymorphisms of TLR2 in patients with cutaneous leishmaniasis (CL) compared to healthy controls. The polymorphisms were genotyped by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) and amplification refractory mutation system assay (ARMS-PCR). The results showed that the frequency of Arg753Gln genotype was 14.3% and 10.1% in CL patients and normal controls, respectively. No one in either group was homozygous for the mutation. There was no significant difference in the genotype frequency. In contrast to the results for Arg753Gln polymorphism, we did not detect any case with Arg677Trp polymorphism in either control or patient group. In conclusion the TLR2 mutations are found equally in CL patients and healthy subjects. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：466 / 468

页数：3

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