The Role of the ACE2/MasR Axis in Ischemic Stroke: New Insights for Therapy

被引：13
作者：
Barzegar, Mansoureh [1 ]
Stokes, Karen Y. [1 ]
Chernyshev, Oleg [2 ]
Kelley, Roger E. [2 ]
Alexander, Jonathan S. [1 ,2 ,3 ,4 ]
机构：
[1] Ochsner LSU Hlth Sci Ctr, Mol & Cellular Physiol, Shreveport, LA 71130 USA
[2] Ochsner LSU Hlth Sci Ctr, Neurol, Shreveport, LA 71130 USA
[3] LSU Hlth Ctr, Med, 1501 Kings Highway, Shreveport, LA 71130 USA
[4] Ochsner LSU Hlth Sci Ctr, Oral & Maxillofacial Surg, Shreveport, LA 71130 USA
来源：
BIOMEDICINES | 2021年 / 9卷 / 11期
基金：
美国国家卫生研究院;
关键词：
ischemic stroke; angiotensin converting enzyme-2; MasR; therapy; CONVERTING-ENZYME ACE; ANGIOTENSIN-II; NITRIC-OXIDE; AT2; RECEPTOR; BRAIN; RELEASE; FLOW; REPERFUSION; ACTIVATION; EXPRESSION;
D O I：
10.3390/biomedicines9111667
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ischemic stroke remains the leading cause of neurologically based morbidity and mortality. Current stroke treatment is limited to two classes of FDA-approved drugs: thrombolytic agents (tissue plasminogen activator (tPA)) and antithrombotic agents (aspirin and heparin), which have a narrow time-window (<4.5 h) for administration after onset of stroke symptoms. While thrombolytic agents restore perfusion, they carry serious risks for hemorrhage, and do not influence damage responses during reperfusion. Consequently, stroke therapies that can suppress deleterious effects of ischemic injury are desperately needed. Angiotensin converting enzyme-2 (ACE2) has been recently suggested to beneficially influence experimental stroke outcomes by converting the vasoconstrictor Ang II into the vasodilator Ang 1-7. In this review, we extensively discuss the protective functions of ACE2-Ang (1-7)-MasR axis of renin angiotensin system (RAS) in ischemic stroke.
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页数：18
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