Anti-tumor-promoting activity of lignans from the aerial part of Saussurea medusa

被引：182

作者：

Takasaki, M

Konoshima, T ^{[1
]}

Komatsu, K

Tokuda, H

Nishino, H

机构：

[1] Kyoto Pharmaceut Univ, Yamashina Ku, Kyoto 6078414, Japan

[2] Toyama Med & Pharmaceut Univ, Res Inst Wakan Yaku, Toyama 9300194, Japan

[3] Kyoto Prefectural Univ Med, Dept Biochem, Kamigyo Ku, Kyoto 6020841, Japan

来源：

CANCER LETTERS | 2000年 / 158卷 / 01期

关键词：

cancer chemopreventive activity; lignan; arctiin; Saussurea medusa; anti-tumor-promoter; pulmonary tumor inhibitor;

D O I：

10.1016/S0304-3835(00)00499-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In the course of our continuing search for novel cancer chemopreventive agents from natural sources, several kinds of Compositae plants were screened. Consequently, the lignans, arctiin (ARC) and arctigenin (ARC-G), were obtained from the aerial part of Saussurea medusa as active constituents. These compounds exhibited the remarkable anti-tumor-promoting effect on two-stage carcinogenesis test of mouse skin tumors induced by 7,12-dimethylbenz[a]anthracene as an initiator and 12-O-tetradecanoyl phorbol-13-acetate as a promoter by both topical application and oral administration. Furthermore, ARC-G exhibited potent anti-tumor-promoting activity on two-stage carcinogenesis test of mouse pulmonary tumors induced by 4-nitroquinoline-N-oxide as an initiator and glycerol as a promoter. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：53 / 59

页数：7

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