Cu(i)-Catalyzed asymmetric intramolecular addition of aryl pinacolboronic esters to unactivated ketones: enantioselective synthesis of 2,3-dihydrobenzofuran-3-ol derivatives

被引：17
作者：
Ni, Chunjie [1 ,2 ]
Gao, Jihui [1 ]
Fang, Xianjie [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai Key Lab Mol Engn Chiral Drugs, 800 Dongchuan Rd, Shanghai 200240, Peoples R China
[2] Yancheng Teachers Univ, Sch Pharm, Yancheng 224051, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 17期
基金：
中国博士后科学基金;
关键词：
RHODIUM-CATALYZED ADDITION; CROSS-COUPLING REACTIONS; ARYLBORONIC ACIDS; PHOSPHORUS LIGANDS; ALPHA-DIKETONES; SUZUKI-MIYAURA; NAPHTHOQUINONES; 1,2-ADDITION; DIARYLATION; ALCOHOLS;
D O I：
10.1039/c9cc09653a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An (S,S)-QuinoxP*-supported Cu(i) catalyst has been disclosed for highly enantioselective intramolecular addition of aryl pinacolboronic esters to unactivated ketones under mild reaction conditions. This protocol showcases a broad substrate tolerance and allows access to various chiral 2,3-dihydrobenzofuran-3-ol derivatives in generally good yields with excellent enantioselectivities.
引用
收藏
页码：2654 / 2657
页数：4
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