Review article: current and future treatment approaches for IBS with constipation

被引：7

作者：

Liu, Joy J. ^{[1
]}

Brenner, Darren M. ^{[1
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Div Gastroenterol, Chicago, IL 60611 USA

来源：

ALIMENTARY PHARMACOLOGY & THERAPEUTICS | 2021年 / 54卷

关键词：

IRRITABLE-BOWEL-SYNDROME; CONTROLLED-TRIAL; VISCERAL HYPERSENSITIVITY; EVALUATE EFFICACY; DOUBLE-BLIND; LINACLOTIDE; MANAGEMENT; SAFETY; 12-WEEK; LUBIPROSTONE;

D O I：

10.1111/apt.16607

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background Multiple efficacious therapies are currently available for treating irritable bowel syndrome with constipation (IBS-C). IBS-C specific survey tools that assess symptom relief, treatment satisfaction, and quality of life are important for gauging real-world effectiveness. Aims/Methods This article reviews clinical trial efficacy data as well as survey data on adequate relief and quality of life from pivotal trials for lubiprostone, linaclotide, plecanatide, tenapanor, and tegaserod. A brief discussion of agents in development with novel mechanisms of action is also provided. Results/Conclusions Quality of life and symptom metrics should be standardized and continue to be represented in future IBS-C trials. The choice of agent should be tailored to probability of improving symptoms, safety, tolerability, and cost.

引用

页码：S53 / S62

页数：10

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