Lignin as a Natural Carrier for the Efficient Delivery of Bioactive Compounds: From Waste to Health

被引：34

作者：

Verdini, Federico ^{[1
]}

Gaudino, Emanuela Calcio ^{[1
]}

Canova, Erica ^{[1
,2
]}

Tabasso, Silvia ^{[1
]}

Behbahani, Paria Jafari ^{[1
]}

Cravotto, Giancarlo ^{[1
]}

机构：

[1] Univ Turin, Dipartimento Sci & Tecnol Farmaco, Via P Giuria 9, I-10125 Turin, Italy

[2] Huvepharma Italia Srl, Via Roberto Lepetit 142, I-12075 Garessio, Italy

来源：

MOLECULES | 2022年 / 27卷 / 11期

关键词：

lignin; renewable material; extraction techniques; nanoparticles; drug carrier; DRUG-DELIVERY; ANTIBACTERIAL ACTIVITY; NANOPARTICLES; FABRICATION; GREEN; ANTIOXIDANT; STRATEGIES; CONVERSION; SOLVENT;

D O I：

10.3390/molecules27113598

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lignin is a fascinating aromatic biopolymer with high valorization potentiality. Besides its extensive value in the biorefinery context, as a renewable source of aromatics lignin is currently under evaluation for its huge potential in biomedical applications. Besides the specific antioxidant and antimicrobial activities of lignin, that depend on its source and isolation procedure, remarkable progress has been made, over the last five years, in the isolation, functionalization and modification of lignin and lignin-derived compounds to use as carriers for biologically active substances. The aim of this review is to summarize the current state of the art in the field of lignin-based carrier systems, highlighting the most important results. Furthermore, the possibilities and constraints related to the physico-chemical properties of the lignin source will be reviewed herein as well as the modifications and processing required to make lignin suitable for the loading and release of active compounds.

引用

收藏

页数：24

相关论文

共 91 条

[1] Rapid and Direct Preparation of Lignin Nanoparticles from Alkaline Pulping Liquor by Mild Ultrasonication [J].

Agustin, Melissa B. ;

Penttila, Paavo A. ;

Lahtinen, Maarit ;

Mikkonen, Kirsi S. .

ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 2019, 7 (24) :19925-+

[2] Lignin Profiling: A Guide for Selecting Appropriate Lignins as Precursors in Biomaterials Development [J].

Ahvazi, Behzad ;

Cloutier, Eric ;

Wojciechowicz, Olivia ;

Tri-Dung Ngo .

ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 2016, 4 (10) :5090-5105

[3] Wound-healing potential of curcumin loaded lignin nanoparticles [J].

Alqahtani, Mohammed S. ;

Alqahtani, Ali ;

Kazi, Mohsin ;

Ahmad, Muhammad Z. ;

Alahmari, Abdullah ;

Alsenaidy, Mohammad A. ;

Syed, Rabbani .

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2020, 60

[4] Novel lignin nanoparticles for oral drug delivery [J].

Alqahtani, Mohammed S. ;

Alqahtani, Ali ;

Al-Thabit, Abdullah ;

Roni, Monzurul ;

Syed, Rabbani .

JOURNAL OF MATERIALS CHEMISTRY B, 2019, 7 (28) :4461-4473

[5] Antimicrobial Activity of Lignin and Lignin-Derived Cellulose and Chitosan Composites against Selected Pathogenic and Spoilage Microorganisms [J].

Alzagameem, Abla ;

Klein, Stephanie Elisabeth ;

Bergs, Michel ;

Do, Xuan Tung ;

Korte, Imke ;

Dohlen, Sophia ;

Huewe, Carina ;

Kreyenschmidt, Judith ;

Kamm, Birgit ;

Larkins, Michael ;

Schulze, Margit .

POLYMERS, 2019, 11 (04)

[6] A concise review of current lignin production, applications, products and their environmental impact [J].

Bajwa, D. S. ;

Pourhashem, G. ;

Ullah, A. H. ;

Bajwa, S. G. .

INDUSTRIAL CROPS AND PRODUCTS, 2019, 139

[7] Optimized synthesis of lignin sulfonate nanoparticles by solvent shifting method and their application for adsorptive removal of dye pollutant [J].

Behboudi, Gity ;

Shayesteh, Keivan ;

Yaraki, Mohammad Tavakkoli ;

Ebrahimi, Hosein Ali ;

Moradi, Samira .

CHEMOSPHERE, 2021, 285

[8] Direct Precipitation of Lignin Nanoparticles from Wheat Straw Organosolv Liquors Using a Static Mixer [J].

Beisl, Stefan ;

Adamcyk, Johannes ;

Friedl, Anton .

MOLECULES, 2020, 25 (06)

[9] Lignins from sugarcane bagasse: Renewable source of nanoparticles as Pickering emulsions stabilizers for bioactive compounds encapsulation [J].

Bertolo, Mirella R., V ;

Brenelli de Paiva, Livia B. ;

Nascimento, Viviane M. ;

Gandin, Cesar A. ;

Neto, Mario O. ;

Driemeier, Carlos E. ;

Rabelo, Sarita C. .

INDUSTRIAL CROPS AND PRODUCTS, 2019, 140

[10] New Insights on the Chemical Modification of Lignin: Acetylation versus Silylation [J].

Buono, Pietro ;

Duval, Antoine ;

Verge, Pierre ;

Averous, Luc ;

Habibi, Youssef .

ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 2016, 4 (10) :5212-5222

← 1 2 3 4 5 6 7 8 9 10 →