PI3k/AKT signaling pathway: Erythropoiesis and beyond

被引：289

作者：

Jafari, Mahjoobeh ^{[1
]}

Ghadami, Elham ^{[1
]}

Dadkhah, Tahereh ^{[1
]}

Akhavan-Niaki, Haleh ^{[1
]}

机构：

[1] Babol Univ Med Sci, Dept Genet, Fac Med, Gandj Afrouz Ave, Babol Sar 4717647745, Iran

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2019年 / 234卷 / 03期

关键词：

erythropoiesis; microRNA (miRNA); PI3K; CREB-BINDING-PROTEIN; TRANSCRIPTION FACTOR GATA-1; REGULATES ERYTHROID-DIFFERENTIATION; GENE-EXPRESSION; CELL-CYCLE; PHOSPHATIDYLINOSITOL; 3-KINASE; PHOSPHOINOSITIDE; 3-KINASES; AKT-PHOSPHORYLATION; PROGENITOR CELLS; KINASE PATHWAY;

D O I：

10.1002/jcp.27262

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Erythropoiesis is a multi-step process that involves the differentiation of hematopoietic stem cells into mature red blood cells (RBCs). This process is regulated by several signaling pathways, transcription factors and microRNAs (miRNAs). Many studies have shown that dysregulation of this process can lead to hematologic disorders. PI3K/AKT is one of the most important pathways that control many cellular processes including, cell division, autophagy, survival, and differentiation. In this review, we focus on the role of PI3K/AKT pathway in erythropoiesis and discuss the function of some of the most important genes, transcription factors, and miRNAs that regulate different stages of erythropoiesis which play roles in differentiation and maturation of RBCs, prevention of apoptosis, and autophagy induction. Understanding the role of the PI3K pathway in erythropoiesis may provide new insights into diagnosing erythrocyte disorders.

引用

页码：2373 / 2385

页数：13

共 166 条

[1] Tumor microenvironment and noncoding RNAs as co-drivers of epithelial-mesenchymal transition and cancer metastasis [J].

Alsibai, Kinan Drak ;

Meseure, Didier .

DEVELOPMENTAL DYNAMICS, 2018, 247 (03) :405-431

[2] Role of translocation in the activation and function of protein kinase B [J].

Andjelkovic, M ;

Alessi, DR ;

Meier, R ;

Fernandez, A ;

Lamb, NJC ;

Frech, M ;

Cron, P ;

Cohen, P ;

Lucocq, JM ;

Hemmings, BA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (50) :31515-31524

[3] Co-operative signalling mechanisms required for erythroid precursor expansion in response to erythropoietin and stem cell factor [J].

Arcasoy, MO ;

Jiang, XH .

BRITISH JOURNAL OF HAEMATOLOGY, 2005, 130 (01) :121-129

[4] MicroRNA-96 Directly Inhibits γ-Globin Expression in Human Erythropoiesis [J].

Azzouzi, Imane ;

Moest, Hansjoerg ;

Winkler, Jeannine ;

Fauchere, Jean-Claude ;

Gerber, Andre P. ;

Wollscheid, Bernd ;

Stoffel, Markus ;

Schmugge, Markus ;

Speer, Oliver .

PLOS ONE, 2011, 6 (07)

[5] Akt-mediated regulation of NFκB and the essentialness of NFκB for the oncogenicity of PI3K and Akt [J].

Bai, Dong ;

Ueno, Lynn ;

Vogt, Peter K. .

INTERNATIONAL JOURNAL OF CANCER, 2009, 125 (12) :2863-2870

[6] Differential regulation of Foxo3a target genes in erythropoiesis [J].

Bakker, Walbert J. ;

van Dijk, Thamar B. ;

Parren-van Amelsvoort, Martine ;

Kolbus, Andrea ;

Yamamoto, Kazuo ;

Steinlein, Peter ;

Verhaak, Roel G. W. ;

Mak, Tak W. ;

Beug, Hartmut ;

Lowenberg, Bob ;

von Lindern, Marieke .

MOLECULAR AND CELLULAR BIOLOGY, 2007, 27 (10) :3839-3854

[7] FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1 [J].

Bakker, WJ ;

Blázquez-Domingo, M ;

Kolbus, A ;

Besooyen, J ;

Steinlein, P ;

Beug, H ;

Coffer, PJ ;

Löwenberg, B ;

von Lindern, M ;

van Dijk, TB .

JOURNAL OF CELL BIOLOGY, 2004, 164 (02) :175-184

[8] GATA-1 and c-myb crosstalk during red blood cell differentiation through GATA-1 binding sites in the c-myb promoter [J].

Bartunek, P ;

Králová, J ;

Blendinger, G ;

Dvorák, M ;

Zenke, M .

ONCOGENE, 2003, 22 (13) :1927-1935

[9] Autophagy facilitates organelle clearance during differentiation of human erythroblasts: Evidence for a role for ATG4 paralogs during autophagosome maturation [J].

Betin, Virginie M. S. ;

Singleton, Belinda K. ;

Parsons, Stephen F. ;

Anstee, David J. ;

Lane, Jon D. .

AUTOPHAGY, 2013, 9 (06) :881-893

[10] Expression of miR-210 during erythroid differentiation and induction of γ-globin gene expression [J].

Bianchi, Nicoletta ;

Zuccato, Cristina ;

Lampronti, Ilaria ;

Borgatti, Monica ;

Gambari, Roberto .

BMB REPORTS, 2009, 42 (08) :493-499

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