Current status of clinical islet transplantation

被引：124

作者：

Korsgren, O ^{[1
]}

Nilsson, B

Berne, C

Felldin, M

Foss, A

Kallen, R

Lundgren, T

Salmela, K

Tibell, A

Tufveson, G

机构：

[1] Univ Uppsala Hosp, Dept Radiol Oncol & Clin Immunol, Div Clin Immunol, Rudbeck Lab, SE-75185 Uppsala, Sweden

[2] Univ Uppsala Hosp, Div Med, Dept Med Sci, SE-75185 Uppsala, Sweden

[3] Univ Hosp Gothenburg, Dept Surg Sci, Div Transplantat Surg, Gothenburg, Sweden

[4] Univ Hosp Oslo, Dept Transplantat Surg, Oslo, Norway

[5] Univ Hosp Malmo, Dept Nephrol & Transplantat, Malmo, Sweden

[6] Karolinska Inst, Dept Transplantat Surg, Stockholm, Sweden

[7] Univ Helsinki, Surg Hosp, Div Transplantat, Helsinki, Finland

[8] Univ Uppsala Hosp, Dept Surg Sci, Div Transplantat Surg, Uppsala, Sweden

来源：

TRANSPLANTATION | 2005年 / 79卷 / 10期

关键词：

D O I：

10.1097/01.TP.0000157273.60147.7C

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Islet transplantation is currently being explored as a treatment for patients with type I diabetes. At present, the number of patients becoming insulin-independent is rapidly increasing world-wide applying the transplantation protocol originally described by the group in Edmonton. A hallmark in this procedure is repeated infusions of islets obtained from 2 to 4 donors until normoglycemia is achieved. In order to establish islet transplantation as a widely accepted treatment modality, and make tolerance induction regimes applicable, it is essential that the donorrecipient ratio is brought down to 1: 1. A conceivable strategy to achieve this goal in clinical islet transplantation is discussed.

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收藏

页码：1289 / 1293

页数：5

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