Coumarin metabolic routes in Aspergillus spp.

被引：22

作者：

Aguirre-Pranzoni, Celeste ^{[1
]}

Orden, Alejandro A. ^{[1
]}

Bisogno, Fabricio R. ^{[1
]}

Ardanaz, Carlos E. ^{[1
]}

Tonn, Carlos E. ^{[1
]}

Kurina-Sanz, Marcela ^{[1
]}

机构：

[1] Univ Nacl San Luis, Fac Quim Bioquim & Farm, INTEQUI CONICET, San Luis, Argentina

来源：

FUNGAL BIOLOGY | 2011年 / 115卷 / 03期

关键词：

Aspergillus; Coumarin; Dihydrocoumarin; Hydroxycoumarin; Metabolism; OLD YELLOW ENZYME; CYTOCHROME-P450; MONOOXYGENASES; CINNAMIC ACID; BIOTRANSFORMATIONS; DIHYDROCOUMARIN; IDENTIFICATION; DERIVATIVES; DIVERSITY;

D O I：

10.1016/j.funbio.2010.12.009

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Coumarin metabolism by several Aspergillus strains was studied. Aspergillus ochraceus and Aspergillus niger carried out the reduction of the C3-C4 double bond to yield dihydrocoumarin in 24 h. Meanwhile, the first strain did not transform dihydrocoumarin after 7 d, A. niger demonstrated to have two divergent catabolic pathways: (a) the lactone moiety opening and further reduction of the carboxylic acid furnishing the primary alcohol 2-(3-hydroxypropyl)phenol and, (b) the hydroxylation of the aromatic ring of dihydrocoumarin at a specific position to give 6-hydroxy-3,4-dihydrochromen-2-one. Aspergillus flavus did not perform double bond reductions, and only produced oxygenated metabolites, mainly 5-hydroxycoumarin. Enzyme-specific inhibitors and a coumarin analogous were useful to confirm the A. niger catabolic route. (C) 2010 The British Mycological Society. Published by Elsevier Ltd. All rights reserved.

引用

页码：245 / 252

页数：8

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