Successful treatment of refractory status asthmaticus with omalizumab: a case report

被引：7

作者：

Benes, Jan ^{[1
,2
]}

Skulec, Roman ^{[1
,2
,3
,4
,7
]}

Jilek, Dalibor ^{[8
]}

Fibigr, Ondrej ^{[9
,10
]}

Cerny, Vladimir ^{[2
,3
,5
,6
]}

机构：

[1] Charles Univ Prague, Univ Hosp Hradec Kralove, Fac Med Hradec Kralove, Hradec Kralove, Czech Republic

[2] Univ JE Purkyne, Masaryk Hosp, Dept Anesthesiol Perioperat Med & Intens Care, Usti Nad Labem, Czech Republic

[3] Univ JE Purkyne, Fac Hlth Studies, Usti Nad Labem, Czech Republic

[4] Charles Univ Prague, Univ Hosp Hradec Kralove, Dept Anesthesiol & Intens Care, Fac Med Hradec Kralove, Hradec Kralove, Czech Republic

[5] Charles Univ Prague, Fac Med Hradec Kralove, Dept Anesthesiol & Intens Care, Ctr Res & Dev, Hradec Kralove, Czech Republic

[6] Dalhousie Univ, Dept Anesthesia Pain Management & Perioperat Med, Halifax, NS, Canada

[7] Emergency Med Serv Cent Bohemian Reg, Kladno, Czech Republic

[8] Univ JE Purkyne, Masaryk Hosp, Dept Clin Immunol & Allergol, Usti Nad Labem, Czech Republic

[9] Charles Univ Prague, Fac Med 3, Dept Pneumol, Prague, Czech Republic

[10] Univ Hosp Bulovka, Prague, Czech Republic

来源：

ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY | 2021年 / 17卷 / 01期

关键词：

ANTI-IGE; THERAPY;

D O I：

10.1186/s13223-021-00629-z

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Refractory status asthmaticus is the cause of rare cases of in-hospital death due to acute bronchial asthma. The most severe cases unresponsive to first, second and next line treatment may be fatal despite aggressive organ support with invasive ventilation and extracorporeal membrane oxygenation. Omalizumab, a humanized recombinant monoclonal anti-IgE antibody, is an approved add-on biological treatment for severe asthma. However, it is not indicated in an acute setting. Here, we report the case of a young patient with status asthmaticus fully dependent on extracorporeal membrane oxygenation refractory to any therapy for six days, who was successfully treated with omalizumab.

引用

页数：6

共 10 条

[1] Randomized Trial of Omalizumab (Anti-IgE) for Asthma in Inner-City Children [J].