Renal Clearable Organic Nanocarriers for Bioimaging and Drug Delivery

被引：125
作者：
Kang, Homan [1 ,2 ,8 ,9 ]
Gravier, Julien [1 ,2 ,3 ,4 ]
Bao, Kai [1 ,2 ,8 ,9 ]
Wada, Hideyuki [1 ,2 ,10 ]
Lee, Jeong Heon [1 ,2 ,8 ,9 ]
Baek, Yoonji [1 ,2 ,8 ,9 ]
El Fakhri, Georges [1 ,2 ,8 ,9 ]
Gioux, Sylvain [1 ,2 ,11 ]
Rubin, Brian P. [5 ,6 ,7 ]
Coll, Jean-Luc [3 ,4 ]
Choi, Hak Soo [1 ,2 ,8 ,9 ]
机构：
[1] Beth Israel Deaconess Med Ctr, Dept Med, Div Hematol Oncol, Boston, MA 02215 USA
[2] Harvard Med Sch, Boston, MA 02215 USA
[3] Univ Grenoble Alpes, Inst Albert Bonniot, F-38000 Grenoble, France
[4] INSERM, U1209, F-38000 Grenoble, France
[5] Cleveland Clin, Dept Anat Pathol, Robert J Tomsich Pathol & Lab Med Inst, Lerner Res Inst, Cleveland, OH 44195 USA
[6] Cleveland Clin, Dept Canc Biol, Robert J Tomsich Pathol & Lab Med Inst, Lerner Res Inst, Cleveland, OH 44195 USA
[7] Cleveland Clin, Taussig Canc Ctr, Cleveland, OH 44195 USA
[8] Massachusetts Gen Hosp, Dept Radiol, Gordon Ctr Med Imaging, Boston, MA 02114 USA
[9] Harvard Med Sch, Boston, MA 02114 USA
[10] Hokkaido Univ, Grad Sch Med, Dept Surg Gastroenterol 2, Sapporo, Hokkaido 0608638, Japan
[11] Univ Strasbourg, ICube Lab, F-67412 Illkirch Graffenstaden, France
来源：
ADVANCED MATERIALS | 2016年 / 28卷 / 37期
关键词：
drug delivery; nanoparticles; optical imaging; renal clearance; theranostics; SILICA NANOPARTICLES; CANCER; PLATFORM; THERAPY; LIPOSOMES; SYSTEM; SIZE;
D O I：
10.1002/adma.201601101
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Renally cleared zwitterionic nanocarriers (H-Dots) are composed of a epsilon-polylysine backbone for charge variations, near-infrared fluorophores for bioimaging, and beta-cyclodextrins for potential drug delivery. H-Dots show ideal systemic circulation and rapid distribution, and excrete from normal tissue/organ via renal excretion after complete targeting to the tumor site without nonspecific uptake by the immune system.
引用
收藏
页码：8162 / 8168
页数：7
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