Intractable Vomiting as the Initial Presentation of Neuromyelitis Optica

被引：162

作者：

Apiwattanakul, Metha ^{[2
]}

Popescu, Bogdan F. ^{[1
]}

Matiello, Marcelo ^{[1
]}

Weinshenker, Brian G. ^{[1
]}

Lucchinetti, Claudia F. ^{[1
]}

Lennon, Vanda A. ^{[1
,2
,3
]}

McKeon, Andrew ^{[2
]}

Carpenter, Adam F. ^{[5
]}

Miller, Gary M. ^{[4
]}

Pittock, Sean J. ^{[1
,2
]}

机构：

[1] Mayo Clin, Dept Neurol, Coll Med, Rochester, MN 55905 USA

[2] Mayo Clin, Dept Lab Med & Pathol, Coll Med, Rochester, MN 55905 USA

[3] Mayo Clin, Dept Immunol, Coll Med, Rochester, MN 55905 USA

[4] Mayo Clin, Dept Radiol, Coll Med, Rochester, MN 55905 USA

[5] Univ Minnesota, Dept Neurol, Minneapolis, MN 55455 USA

来源：

ANNALS OF NEUROLOGY | 2010年 / 68卷 / 05期

关键词：

AREA POSTREMA; EXPRESSION; TRANSPORT; LESIONS; MARKER;

D O I：

10.1002/ana.22121

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report 12 aquaporin-4 antibody-positive patients (12% of seropositive Mayo Clinic patients identified since 2005) whose initial presenting symptom of neuromyelitis optica was intractable vomiting. The initial evaluation in 75% was gastroenterologic. Vomiting lasted a median of 4 weeks (range, 2 days-80 weeks). Optic neuritis or transverse myelitis developed after vomiting onset in 11 patients (median interval, 11 weeks; range, 1-156). At last evaluation (median, 48 months after vomiting onset), 7 patients fulfilled neuromyelitis optica diagnostic criteria. Our clinical, pathologic and neuroimaging observations suggest the aquaporin-4-rich area postrema may be a first point of attack in neuromyelitis optica. ANN NEUROL 2010;68:757-761

引用

页码：757 / 761

页数：5

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