A carcinoembryonic antigen-related cell adhesion molecule 1 homologue plays a pivotal role in nontypeable Haemophilus influenzae colonization of the chinchilla nasopharynx via the outer membrane protein P5-homologous adhesin

被引：45

作者：

Bookwalter, James E. ^{[1
]}

Jurcisek, Joseph A. ^{[1
]}

Gray-Owen, Scott D. ^{[2
]}

Fernandez, Soledad ^{[3
]}

McGillivary, Glen ^{[1
]}

Bakaletz, Lauren O. ^{[1
]}

机构：

[1] Ohio State Univ, Coll Med, Ctr Microbial Pathogenesis, Res Inst Nationwide Childrens Hosp,Dept Pediat, Columbus, OH 43205 USA

[2] Univ Toronto, Dept Med Genet & Microbiol, Toronto, ON M5S 1A8, Canada

[3] Ohio State Univ, Coll Publ Hlth, Ctr Biostat, Columbus, OH 43210 USA

来源：

INFECTION AND IMMUNITY | 2008年 / 76卷 / 01期

关键词：

D O I：

10.1128/IAI.00980-07

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In vitro studies suggest an important role for CEACAM1 (carcinoembryonic antigen-related cell adhesion molecule 1) in infection by multiple gram-negative bacteria. However, in vivo evidence supporting this role is lacking, largely because the bacterial adhesins involved in this host-microbe association do not bind to murine-derived CEACAM1. One of several adhesins expressed by nontypeable Haemophilus influenzae (NTHI), the outer membrane protein P5-homologous adhesin (or P5), is essential for colonization of the chinchilla nasopharynx and infection of the middle ear. Here we reveal that NTHI P5 binds to the chinchilla homologue of CEACAM1 and that rabbit anti-human carcinoembryonic antigen blocks NTHI colonization of the chinchilla nasopharynx, providing the first demonstration of a role for CEACAM receptor binding by any bacterial pathogen in vivo.

引用

页码：48 / 55

页数：8

共 56 条

[1] Respiratory viruses augment the adhesion of bacterial pathogens to respiratory epithelium in a viral species- and cell type-dependent manner [J].