Differentially Aquaporin 5 Expression in Submandibular Glands and Cerebral Cortex in Alzheimer's Disease

被引：6

作者：

Antequera, Desiree ^{[1
,2
]}

Carrero, Laura ^{[1
,2
]}

Cunha Alves, Victoria ^{[1
,2
]}

Ferrer, Isidro ^{[2
,3
,4
,5
]}

Hernandez-Gallego, Jesus ^{[1
,2
,6
,7
]}

Municio, Cristina ^{[1
,2
]}

Carro, Eva ^{[2
,8
]}

机构：

[1] Hosp Univ 12 Octubre, Grp Neurodegenerat Dis, Res Inst Imas12, Madrid 28041, Spain

[2] ISCIII, Network Ctr Biomed Res Neurodegenerat Dis CIBERNE, Madrid 28031, Spain

[3] Bellvitge Biomed Res Inst IDIBELL, Lhospitalet De Llobregat 08908, Spain

[4] Univ Barcelona, Dept Pathol & Expt Therapeut, Lhospitalet De Llobregat 08907, Spain

[5] Univ Barcelona, Inst Neurosci, Barcelona 08035, Spain

[6] Hosp Univ 12 Octubre, Dept Neurol, Madrid 28041, Spain

[7] Univ Complutense Madrid, Fac Med, Dept Med, Madrid 28040, Spain

[8] Inst Salud Carlos III, Neurobiol Alzheimers Dis Unit, Chron Dis Programme, Majadahonda 28222, Spain

来源：

BIOMEDICINES | 2022年 / 10卷 / 07期

关键词：

Alzheimer's disease; aquaporins; submandibular gland; astrocytes; neurons; SALIVARY SECRETION; DOWN-REGULATION; WATER CHANNELS; PARASYMPATHETIC DENERVATION; AQP5; ASSOCIATION; ASTROCYTES; ROLES; BRAIN; LOCALIZATION;

D O I：

10.3390/biomedicines10071645

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Impaired brain clearance mechanisms may result in the accumulation of aberrant proteins that define Alzheimer's disease (AD). The water channel protein astrocytic aquaporin 4 (AQP4) is essential for brain amyloid-beta clearance, but it is known to be abnormally expressed in AD brains. The expression of AQPs is differentially regulated during diverse brain injuries, but, whereas AQP4 expression and function have been studied in AD, less is known about AQP5. AQP5 functions include not only water transport but also cell migration mediated by cytoskeleton regulation. Moreover, AQP5 has been reported to be expressed in astrocytes, which are regulated after ischemic and traumatic injury. Additionally, AQP5 is particularly abundant in the salivary glands suggesting that it may be a crucial factor in gland dysfunction associated with AD. Herein, we aim to determine whether AQP5 expression in submandibular glands and the brain was altered in AD. First, we demonstrated impaired AQP5 expression in submandibular glands in APP/PS1 mice and AD patients. Subsequently, we observed that AQP5 expression was upregulated in APP/PS1 cerebral cortex and confirmed its expression both in astrocytes and neurons. Our findings propose AQP5 as a significant role player in AD pathology, in addition to AQP4, representing a potential target for the treatment of AD.

引用

页数：16