Impact of early CMV reactivation in cord blood stem cell recipients in the current era

被引：37

作者：

Ramanathan, M. ^{[1
,19
]}

Teira, P. ^{[2
]}

Battiwalla, M. ^{[3
]}

Barrett, J. ^{[3
]}

Ahn, K. W. ^{[4
,5
]}

Chen, M. ^{[5
]}

Green, J. ^{[6
]}

Laughlin, M. ^{[7
]}

Lazarus, H. M. ^{[8
]}

Marks, D. ^{[9
]}

Saadi, A. ^{[10
]}

Seftel, M. ^{[11
]}

Saber, W. ^{[4
]}

Savani, B. ^{[12
]}

Waller, E. K. ^{[13
]}

Wingard, J. ^{[14
]}

Aulettal, J. J. ^{[15
]}

Lindemans, C. A. ^{[16
]}

Boeckh, M. ^{[17
]}

Riches, M. L. ^{[18
]}

机构：

[1] UMass Mem Med Ctr, Dept Med, Div Hematol & Oncol, Worcester, MA USA

[2] Univ Montreal, Sainte Justine Hosp, Montreal, PQ, Canada

[3] Hematol Branch Natl Heart Lung & Blood Inst, Bethesda, MD USA

[4] CIBMTR, Dept Med Med Coll Wisconsin, Milwaukee, WI USA

[5] Med Coll Wisconsin, Div Biostat Inst Hlth & Soc, Milwaukee, WI 53226 USA

[6] Univ Minnesota, Dept Med, Box 736 UMHC, Minneapolis, MN 55455 USA

[7] Med Director Cleveland Cord Blood Ctr, Cleveland, OH USA

[8] Univ Hosp Case Med Ctr, Seidman Canc Ctr, Cleveland, OH USA

[9] Univ Hosp Bristol NHS Trust, Pediat Bone Marrow Transplant, Bristol, Avon, England

[10] Univ Alabama Birmingham, Dept Med, Div Hematol & Oncol, Birmingham, AL USA

[11] Princess Margaret Canc Ctr, Dept Haematol & Med Oncol, Toronto, ON, Canada

[12] Vanderbilt Univ, Ctr Med, Dept Med, Div Hematol & Oncol, Nashville, TN 37232 USA

[13] Emory Univ, Winship Canc Ctr, Dept Hematol & Med Oncol, Atlanta, GA USA

[14] Univ Florida, Dept Med, Dept Hematol & Oncol, Gainesville, FL USA

[15] Nationwide Childrens Hosp, Marrow Transplant & Infect Dis, Div Hematol Oncol Bone, Host Def Program, Columbus, OH USA

[16] Univ Med Ctr Utrecht, Pediat Blood & Marrow Transplantat Program, Utrecht, Netherlands

[17] Vaccine & Infect Dis, Div Fred Hutchinson Canc Res, Seattle, WA USA

[18] Univ N Carolina, Div Hematol & Oncol, Chapel Hill, NC USA

[19] UMASS Med Sch, Med Ctr, 55 Lake Ave North, Worcester, MA 01655 USA

来源：

BONE MARROW TRANSPLANTATION | 2016年 / 51卷 / 08期

关键词：

ACUTE MYELOID-LEUKEMIA; RELAPSE RISK EVIDENCE; T-CELLS; BONE-MARROW; CYTOMEGALOVIRUS REACTIVATION; TRANSPLANT RECIPIENTS; ALLO-SCT; DONOR; DISEASE; SEROSTATUS;

D O I：

10.1038/bmt.2016.89

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Several studies have reported an association between CMV reactivation and a decreased incidence of relapse for AML after adult donor allogeneic hematopoietic cell transplantation (HCT). Limited data, however, are available on the impact of CMV reactivation on relapse after cord blood (CB) stem cell transplantation. The unique combination of higher incidence of CMV reactivation in the seropositive recipient and lower incidence of graft versus host disease (GvHD) in CB HCT permits a valuable design to analyze the impact of CMV reactivation. Data from 1684 patients transplanted with CB between 2003 and 2010 for AML and ALL were analyzed. The median time to CMV reactivation was 34 days (range: 2-287). CMV reactivation and positive CMV serology were associated with increased non-relapse mortality (NRM) among both AML and ALL CB recipients (reactivation, AML: relative risk (RR) 1.41 (1.07-1.85); ALL: 1.60 (1.14-2.23); Serology, AML: RR 1.39 (1.05-1.85), ALL: RR 1.61 (1.18-2.19)). For patients with ALL, but not those with AML, this yielded inferior overall survival (P < 0.005). Risk of relapse was not influenced by CMV reactivation or positive CMV serostatus for either disease.

引用

页码：1113 / 1120

页数：8

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