Gas-phase isolation of diethyl guanosine 5′-monophosphate and its conformational assignment

被引：8

作者：

Asami, Hiroya ^{[2
]}

Tsukamoto, Masaki ^{[1
]}

Hayakawa, Yoshihiro ^{[3
]}

Saigusa, Hiroyuki ^{[2
]}

机构：

[1] Nagoya Univ, Grad Sch Informat Sci, Chikusa Ku, Nagoya, Aichi 4648601, Japan

[2] Yokohama City Univ, Grad Sch Arts & Sci, Kanazawa Ku, Yokohama, Kanagawa 2360027, Japan

[3] Aichi Inst Technol, Fac Engn, Dept Appl Chem, Toyota 4700392, Japan

来源：

PHYSICAL CHEMISTRY CHEMICAL PHYSICS | 2010年 / 12卷 / 42期

关键词：

DOUBLE-RESONANCE SPECTROSCOPY; HYDRATED CLUSTERS; BIOMOLECULES; NUCLEOSIDES; PROTECTION; GUANINE; BASES;

D O I：

10.1039/c0cp01105c

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We show that intact neutral molecules of guanosine 5'-monophosphate can be vaporized by laser desorption when its phosphate group is esterified. The UV and IR spectroscopic measurements of this nucleotide reveal the existence of a novel internal hydrogen-bonding conformation of the phosphate group and guanine moiety.

引用

页码：13918 / 13921

页数：4

共 17 条

[1] The Mid-IR spectra of 9-ethyl guanine, guanosine, and 2-Deoxyguanosine
Abo-Riziq, Ali
Crews, Bridgit O.
Compagnon, Isabelle
Oomens, Jos
Meijer, Gerard
Von Helden, Gert
Kabelac, Martin
Hobza, Pavel
de Vries, Mattanjah S.
[J]. JOURNAL OF PHYSICAL CHEMISTRY A, 2007, 111 (31) : 7529 - 7536
[2] Hydration structures of 2′-deoxyguanosine studied by IR-UV double resonance spectroscopy: comparison with guanosine
Asami, Hiroya
Urashima, Shu-hei
Saigusa, Hiroyuki
[J]. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2009, 11 (44) : 10466 - 10472
[3] High-throughput synthesis of HepDirect prodrugs of nucleoside monophosphates
Bookser, Brett C.
Raffaele, Nicholas B.
[J]. JOURNAL OF COMBINATORIAL CHEMISTRY, 2008, 10 (04): : 567 - 572
[4] Facile synthesis of oligodeoxyribonucleotides via the phosphoramidite method without nucleoside base protection
Hayakawa, Y
Kataoka, M
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (48) : 12395 - 12401
[5] NONAQUEOUS OXIDATION OF NUCLEOSIDE PHOSPHITES TO THE PHOSPHATES
HAYAKAWA, Y
UCHIYAMA, M
NOYORI, R
[J]. TETRAHEDRON LETTERS, 1986, 27 (35) : 4191 - 4194
[6] RESONANCE ENHANCED MULTIPHOTON IONIZATION OF NUCLEOSIDES BY USING PULSED-LASER DESORPTION IN SUPERSONIC BEAM MASS-SPECTROMETRY
LI, L
LUBMAN, DM
[J]. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 1989, 88 (2-3) : 197 - 210
[7] REMPI spectroscopy of laser desorbed guanosines
Nir, E
Imhof, P
Kleinermanns, K
de Vries, MS
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (33) : 8091 - 8092
[8] Conformers of guanosines and their vibrations in the electronic ground and excited states, as revealed by double-resonance spectroscopy and ab initio calculations
Nir, E
Hünig, I
Kleinermanns, K
de Vries, MS
[J]. CHEMPHYSCHEM, 2004, 5 (01) : 131 - 137
[9] MODIFICATION OF GUANINE BASES BY NUCLEOSIDE PHOSPHORAMIDITE REAGENTS DURING THE SOLID-PHASE SYNTHESIS OF OLIGONUCLEOTIDES
PON, RT
DAMHA, MJ
OGILVIE, KK
[J]. NUCLEIC ACIDS RESEARCH, 1985, 13 (18) : 6447 - 6465
[10] Getting into shape: Conformational and supramolecular landscapes in small biomolecules and their hydrated clusters
Robertson, EG
Simons, JP
[J]. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2001, 3 (01) : 1 - 18

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