Lipid Ameoliorating and Anti-oxidative potential of Sesamum indicum L. in improving blood lipid profile: A comprehensive review

Sesamum indicum L is an excellent source of unsaturated fatty acids and secondary metabolites. Most commonly used in Eastern and African countries, easily available and cheap source of vital nutrients. The aim of this review was to identify scientific evidences regarding the hypolipidemic and ant oxidative potential of sesame seed and its derivatives. Electronic search of Google scholar, Medline and PubMed databases are conducted. Elevated levels of plasma lipids and cholesterol is known as hyperlipidemia, increased lipids levels are directly associated with vascular and metabolic disorders. Hyperlipidemia is the most common risk factor of cardiovascular diseases. Sesame seed is loaded with vitamin E, sesamin, sesamolin, sesamol, lignans and phytoestrogen, these constituents have potential to reduce hperlipidimia, hypercholesterolimia and elevated triglycerides levels. They also act as antioxidants to prevent lipid peroxidation and oxidative stress. Mechanism behind hypolipidemic effect of sesame seed, is its ability to increase superoxide dismutase SOD and glutathione peroxidase (antioxidants) activity, reduction in triglycerides and Malondialdehyde (MDA) concentration. Previous studies suggested that Sesamum indicum L. is highly effective to manage hyperlidemia and dislipidemia due to its lipid ameliorating and antioxidative effect.