Novel Synthesis of Some New Pyridazine and Pyridazino[4,5-d]pyridazine Derivatives

被引:14
作者
Abdelrazek, Fathy M. [1 ]
Fadda, Ahmed A. [2 ]
Elsayed, Akram N. [1 ]
机构
[1] Cairo Univ, Fac Sci, Dept Chem, Giza, Egypt
[2] Mansoura Univ, Fac Sci, Dept Chem, Mansoura, Egypt
关键词
Dimethylformamide-dimethylacetal; phenacyl-malononitrile; pyridazine; pyridazino[4; 5-d]pyridazine; MOLLUSCICIDAL ACTIVITY; HETEROCYCLIC-SYNTHESIS; NITRILES; PYRAZOLE;
D O I
10.1080/00397911003797809
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
[image omitted] Phenacyl-malononitrile derivatives 1a and b react with dimethylformamide dimethylacetal (DMFDMA) in refluxing toluene to afford the enaminones 2a and b respectively. Compounds 2a and 2b react with the hydrazine hydrate 3a and phenyl hydrazine 3b in refluxing ethanol to afford the pyridazine derivatives 5a-d, presumably via the intermediates 4. Compounds 5a-d, react with hydrazine hydrate 3a to afford the pyridazino[4,5-d]pyridazines 6a-d respectively. The pyridazines 5a and b and the pyridazino[4,5-d] pyridazines 6a and b could be oxidized into the full aromatic systems 7a and b and 8a and b respectively. Compounds 7a and b react also with hydrazine hydrate 3a to afford 8a and b respectively.
引用
收藏
页码:1119 / 1126
页数:8
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