Novel Synthesis of Some New Pyridazine and Pyridazino[4,5-d]pyridazine Derivatives

被引：14

作者：

Abdelrazek, Fathy M. ^{[1
]}

Fadda, Ahmed A. ^{[2
]}

Elsayed, Akram N. ^{[1
]}

机构：

[1] Cairo Univ, Fac Sci, Dept Chem, Giza, Egypt

[2] Mansoura Univ, Fac Sci, Dept Chem, Mansoura, Egypt

来源：

SYNTHETIC COMMUNICATIONS | 2011年 / 41卷 / 08期

关键词：

Dimethylformamide-dimethylacetal; phenacyl-malononitrile; pyridazine; pyridazino[4; 5-d]pyridazine; MOLLUSCICIDAL ACTIVITY; HETEROCYCLIC-SYNTHESIS; NITRILES; PYRAZOLE;

D O I：

10.1080/00397911003797809

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[image omitted] Phenacyl-malononitrile derivatives 1a and b react with dimethylformamide dimethylacetal (DMFDMA) in refluxing toluene to afford the enaminones 2a and b respectively. Compounds 2a and 2b react with the hydrazine hydrate 3a and phenyl hydrazine 3b in refluxing ethanol to afford the pyridazine derivatives 5a-d, presumably via the intermediates 4. Compounds 5a-d, react with hydrazine hydrate 3a to afford the pyridazino[4,5-d]pyridazines 6a-d respectively. The pyridazines 5a and b and the pyridazino[4,5-d] pyridazines 6a and b could be oxidized into the full aromatic systems 7a and b and 8a and b respectively. Compounds 7a and b react also with hydrazine hydrate 3a to afford 8a and b respectively.

引用

页码：1119 / 1126

页数：8

共 23 条

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