Tunable Gold(I)-Catalyzed [4+3] Cycloaddition for Divergent Synthesis of Furan-Fused N,O-Heterocycles

被引：33

作者：

Zhang, Shouzhi ^{[1
]}

Tang, Aijie ^{[1
]}

Chen, Panpan ^{[1
]}

Zhao, Zhiqiang ^{[1
]}

Miao, Maozhong ^{[1
]}

Ren, Hongjun ^{[1
,2
]}

机构：

[1] Zhejiang Sci Tech Univ, Hangzhou, Peoples R China

[2] Taizhou Univ, Taizhou, Peoples R China

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 03期

关键词：

DIASTEREOSELECTIVE 1,3-DIPOLAR CYCLOADDITION; 1-(1-ALKYNYL)CYCLOPROPYL KETONES; 3-COMPONENT REACTION; CATALYZED REACTIONS; ALLENYL KETONES; GOLD CARBENES; METAL; 2-(1-ALKYNYL)-2-ALKEN-1-ONES; NUCLEOPHILES; GENERATION;

D O I：

10.1021/acs.orglett.9b04312

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

By choosing suitable ligand-directed gold catalysts, two types of gold-containing all-carbon 1,4-dipoles could be generated selectively from the gold(I)-catalyzed cycloisomerizations of allenyl ketones bearing a cyclopropyl moiety, which undergo [4 + 3] cycloadditions with nitrones to produce two regiomers of furan-condensed N,O-seven-membered rings in moderate to excellent yields highly selectively.

引用

页码：848 / 853

页数：6

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