808 nm-excited upconversion nanoprobes with low heating effect for targeted magnetic resonance imaging and high-efficacy photodynamic therapy in HER2-overexpressed breast cancer

被引:80
作者
Zeng, Leyong [1 ,2 ,3 ,4 ,5 ]
Pan, Yuanwei [1 ,2 ,3 ,6 ]
Zou, Ruifen [1 ,2 ,3 ]
Zhang, Jinchao [4 ]
Tian, Ying [5 ]
Teng, Zhaogang [5 ]
Wang, Shouju [5 ]
Ren, Wenzhi [1 ,2 ,3 ]
Xiao, Xueshan [6 ]
Zhang, Jichao [7 ]
Zhang, Lili [7 ]
Li, Aiguo [7 ]
Lu, Guangming [5 ]
Wu, Aiguo [1 ,2 ,3 ]
机构
[1] Chinese Acad Sci, Key Lab Magnet Mat & Devices, Ningbo Inst Mat Technol & Engn, Ningbo 315201, Zhejiang, Peoples R China
[2] Chinese Acad Sci, Key Lab Addit Mfg Mat Zhejiang Prov, Ningbo Inst Mat Technol & Engn, Ningbo 315201, Zhejiang, Peoples R China
[3] Chinese Acad Sci, Div Funct Mat & Nanodevices, Ningbo Inst Mat Technol & Engn, Ningbo 315201, Zhejiang, Peoples R China
[4] Hebei Univ, Key Lab Med Chem & Mol Diag, Minist Educ, Chem Biol Key Lab Hebei Prov,Coll Chem & Environm, Baoding 071002, Peoples R China
[5] Nanjing Univ, Sch Med, Jinling Hosp, Dept Med Imaging, Nanjing 210002, Jiangsu, Peoples R China
[6] Shanghai Univ, Inst Mat, Lab Microstruct, Shanghai 200072, Peoples R China
[7] Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Shanghai 201204, Peoples R China
基金
中国国家自然科学基金;
关键词
808 nm-excited upconversion nanoprobes; Low heating effect; High-efficacy photodynamic therapy; HER2-overexpressed breast cancer; LUMINESCENT NANOPARTICLES; OPTICAL-PROPERTIES; IN-VITRO; PHOTOSENSITIZERS; NANOPLATFORM;
D O I
10.1016/j.biomaterials.2016.06.037
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
To avoid the overheating effect of excitation light and improve the efficacy of photodynamic therapy (PDT) of upconversion nanoplatform, a novel nanoprobe based on 808 nm-excited upconversion nanocomposites (T-UCNPs@Ce6@mSiO(2)) with low heating effect and deep penetration has been successfully constructed for targeted upconversion luminescence, magnetic resonance imaging (MRI) and high-efficacy PDT in HER2-overexpressed breast cancer. In this nanocomposite, photosensitizers (Ce6) were covalently conjugated inside of mesoporous silica to enhance the PDT efficacy by shortening the distance of fluorescence resonance energy transfer and to decrease the cytotoxicity by preventing the undesired leakage of Ce6. Compared with UCNPs@mSiO(2)@Ce6, UCNPs@Ce6@mSiO(2) greatly promoted the singlet oxygen generation and amplified the PDT efficacy under the excitation of 808 nm laser. Importantly, the designed nanoprobe can greatly improve the uptake of HER2-positive cells and tumors by modifying the site-specific peptide, and the in vivo experiments showed excellent MRI and PDT via intravenous injection by modeling MDA-MB-435 tumor-bearing nude mice. Our strategy may provide an effective solution for overcoming the heating effect and improving the PDT efficacy of upconversion nanoprobes, and has potential application in visualized theranostics of HER2-overexpressed breast cancer. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码:116 / 127
页数:12
相关论文
共 53 条
[1]   In vivo covalent cross-linking of photon-converted rare-earth nanostructures for tumour localization and theranostics [J].
Ai, Xiangzhao ;
Ho, Chris Jun Hui ;
Aw, Junxin ;
Attia, Amalina Binte Ebrahim ;
Mu, Jing ;
Wang, Yu ;
Wang, Xiaoyong ;
Wang, Yong ;
Liu, Xiaogang ;
Chen, Huabing ;
Gao, Mingyuan ;
Chen, Xiaoyuan ;
Yeow, Edwin K. L. ;
Liu, Gang ;
Olivo, Malini ;
Xing, Bengang .
NATURE COMMUNICATIONS, 2016, 7
[2]   Structure-activity relationship of conformationally constrained peptidomimetics for antiproliferative activity in HER2-overexpressing breast cancer cell lines [J].
Banappagari, Sashikanth ;
Ronald, Sharon ;
Satyanarayanajois, Seetharama D. .
MEDCHEMCOMM, 2011, 2 (08) :752-759
[3]   An Imagable and Photothermal "Abraxane-Like" Nanodrug for Combination Cancer Therapy to Treat Subcutaneous and Metastatic Breast Tumors [J].
Chen, Qian ;
Liang, Chao ;
Wang, Chao ;
Liu, Zhuang .
ADVANCED MATERIALS, 2015, 27 (05) :903-910
[4]   Functional Nanomaterials for Phototherapies of Cancer [J].
Cheng, Liang ;
Wang, Chao ;
Feng, Liangzhu ;
Yang, Kai ;
Liu, Zhuang .
CHEMICAL REVIEWS, 2014, 114 (21) :10869-10939
[5]   In Vivo Targeted Deep-Tissue Photodynamic Therapy Based on Near-Infrared Light Triggered Upconversion Nanoconstruct [J].
Cui, Sisi ;
Yin, Deyan ;
Chen, Yuqi ;
Di, Yingfeng ;
Chen, Haiyan ;
Ma, Yuxiang ;
Achilefu, Samuel ;
Gu, Yueqing .
ACS NANO, 2013, 7 (01) :676-688
[6]   Erythrocyte membrane-coated NIR-triggered biomimetic nanovectors with programmed delivery for photodynamic therapy of cancer [J].
Ding, Hui ;
Lv, Yanlin ;
Ni, Dezhi ;
Wang, Jie ;
Tian, Zhiyuan ;
Wei, Wei ;
Ma, Guanghui .
NANOSCALE, 2015, 7 (21) :9806-9815
[7]   A smart upconversion-based mesoporous silica nanotheranostic system for synergetic chemo-/radio-/photodynamic therapy and simultaneous MR/UCL imaging [J].
Fan, Wenpei ;
Shen, Bo ;
Bu, Wenbo ;
Chen, Feng ;
He, Qianjun ;
Zhao, Kuaile ;
Zhang, Shengjian ;
Zhou, Liangping ;
Peng, Weijun ;
Xiao, Qingfeng ;
Ni, Dalong ;
Liu, Jianan ;
Shi, Jianlin .
BIOMATERIALS, 2014, 35 (32) :8992-9002
[8]   Singlet oxygen-induced apoptosis of cancer cells using upconversion fluorescent nanoparticles as a carrier of photosensitizer [J].
Guo, Huichen ;
Qian, Haisheng ;
Idris, Niagara Muhammad ;
Zhang, Yong .
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2010, 6 (03) :486-495
[9]   Upconversion nanoparticles as versatile light nanotransducers for photoactivation applications [J].
Idris, Niagara Muhammad ;
Jayakumar, Muthu Kumara Gnanasammandhan ;
Bansal, Akshaya ;
Zhang, Yong .
CHEMICAL SOCIETY REVIEWS, 2015, 44 (06) :1449-1478
[10]   In vivo photodynamic therapy using upconversion nanoparticles as remote-controlled nanotransducers [J].
Idris, Niagara Muhammad ;
Gnanasammandhan, Muthu Kumara ;
Zhang, Jing ;
Ho, Paul C. ;
Mahendran, Ratha ;
Zhang, Yong .
NATURE MEDICINE, 2012, 18 (10) :1580-U190