An expanded parenchymal CD8+ T cell clone in GABAA receptor encephalitis

被引：17
作者：
Bracher, Aline [1 ]
Alcala, Carmen [2 ]
Ferrer, Jaime [3 ]
Melzer, Nico [4 ,5 ]
Hohlfeld, Reinhard [1 ,6 ]
Casanova, Bonaventura [2 ]
Beltran, Eduardo [1 ]
Dornmair, Klaus [1 ,6 ]
机构：
[1] Ludwig Maximilians Univ Munchen, Biomed Ctr & Hosp, Inst Clin Neuroimmunol, Munich, Germany
[2] Hosp Univ & Politecn La Fe, Dept Neurol, Valencia, Spain
[3] Hosp Univ & Politecn La Fe, Dept Pathol, Valencia, Spain
[4] Univ Hosp Munster, Clin Neurol, Munster, Germany
[5] Univ Hosp Munster, Inst Translat Neurol, Munster, Germany
[6] Munich Cluster Syst Neurol SyNergy, Munich, Germany
来源：
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY | 2020年 / 7卷 / 02期
关键词：
RASMUSSEN ENCEPHALITIS; MULTIPLE-SCLEROSIS; AUTOANTIBODIES; ANTIBODIES; PERSIST; TUMOR;
D O I：
10.1002/acn3.50974
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The role of T cells in autoimmune encephalitis syndromes with autoantibodies against cell surface antigens is still enigmatic. Here we analyzed the T cell receptor repertoires of CD8+ and CD4+ T cells in a patient with "idiopathic" gamma-aminobutyric-acid-A receptor (GABA(A)-R) encephalitis by next-generation sequencing and single-cell analyses. We identified a CD8+ T cell clone that was strongly expanded in the cerebrospinal fluid and in the hippocampus but not in the operculo-insular cortex. By contrast, CD4+ T cells were polyclonal in these tissues. Such a strong clonal expansion suggests that CD8+ T cells may play a significant role in the pathogenesis.
引用
收藏
页码：239 / 244
页数：6
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