Quantitative online sheath-flow surface enhanced Raman spectroscopy detection for liquid chromatography

被引：32
作者：
Anh Nguyen [1 ]
Schultz, Zachary D. [1 ]
机构：
[1] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA
来源：
ANALYST | 2016年 / 141卷 / 12期
基金：
美国国家科学基金会;
关键词：
SERS DETECTION; SEPARATION; SCATTERING; URINE;
D O I：
10.1039/c6an00155f
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Sheath-flow surface-enhanced Raman spectroscopy (SERS) was used for online detection and quantification of small molecules separated by liquid chromatography. A mixture of model metabolites (thiamine, folic acid, and riboflavin) was separated and characterized by UV-Vis and SERS detectors connected in series. Acetonitrile in the mobile phase provided an internal standard enabling quantitative detection across SERS experiments.
引用
收藏
页码：3630 / 3635
页数：6
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