Diagnostic Capability of Biological Markers in Assessment of Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis

被引：73

作者：

Canto, Graziela De Luca ^{[1
,2
]}

Pacheco-Pereira, Camila ^{[2
]}

Aydinoz, Secil ^{[3
,4
]}

Major, Paul W. ^{[2
]}

Flores-Mir, Carlos ^{[2
]}

Gozal, David ^{[4
]}

机构：

[1] Univ Fed Santa Catarina, Dept Dent, Florianopolis, SC, Brazil

[2] Univ Alberta, Fac Med & Dent, Sch Dent, Edmonton, AB T6G 2M7, Canada

[3] GATA Haydarpasa Teaching Hosp, Istanbul, Turkey

[4] Univ Chicago, Dept Pediat, Chicago, IL 60637 USA

来源：

JOURNAL OF CLINICAL SLEEP MEDICINE | 2015年 / 11卷 / 01期

关键词：

biological markers; diagnosis; sleep apnea syndromes; review; C-REACTIVE PROTEIN; POSITIVE AIRWAY PRESSURE; EXHALED BREATH CONDENSATE; ENDOTHELIAL GROWTH-FACTOR; NECROSIS-FACTOR-ALPHA; OXIDATIVE STRESS; PLASMA-LEVELS; ADHESION MOLECULES; ELEVATED LEVELS; SERUM-LEVELS;

D O I：

10.5664/jcsm.4358

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: The purpose of this systematic review is to evaluate the diagnostic value of biological markers (exhaled breath condensate, blood, salivary and urinary) in the diagnosis of OSA in comparison to the gold standard of nocturnal PSG. Methods: Studies that differentiated OSA from controls based on PSG results, without age restriction, were eligible for inclusion. The sample of selected studies could include studies in obese patients and with known cardiac disease. A detailed individual search strategy for each of the following bibliographic databases was developed: Cochrane, EMBASE, MEDLINE, PubMed, and LILACS. The references cited in these articles were also crosschecked and a partial grey literature search was undertaken using Google Scholar. The methodology of selected studies was evaluated using the 14-item Quality Assessment Tool for Diagnostic Accuracy Studies. Results: After a two-step selection process, nine articles were identified and subjected to qualitative and quantitative analyses. Among them, only one study conducted in children and one in adults found biomarkers that exhibit sufficiently satisfactory diagnostic accuracy that enables application as a diagnostic method for OSA. Conclusion: Kallikrein-1, uromodulin, urocotin-3, and orosomucoid-1 when combined have enough accuracy to be an OSA diagnostic test in children. IL-6 and IL-10 plasma levels have potential to be good biomarkers in identifying or excluding the presence of OSA in adults.

引用

页码：27 / +

页数：16

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