FACILE AND CONVENIENT SYNTHESES OF FLUORINE-CONTAINING PYRIMIDO [5,4-c]QUINOLINES AND BENZO [h][1,6]NAPHTHYRIDINES BY CONDENSATION REACTION OF 2-METHOXY-3-TRIFLUOROACETYL-4-QUINOLYLAMINE WITH ALDEHYDES AND KETONES

被引：3

作者：

Hatakenaka, Mizuki ^{[1
]}

Okada, Etsuji ^{[1
]}

机构：

[1] Kobe Univ, Grad Sch Engn, Dept Chem Sci & Engn, Nada Ku, Rokkodai Cho, Kobe, Hyogo 6578501, Japan

来源：

HETEROCYCLES | 2017年 / 94卷 / 01期

关键词：

DERIVATIVES; ANTAGONISTS; QUINOLINES; DESIGN;

D O I：

10.3987/COM-16-13595

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Methoxy-3-trifluoroacetyl-4-quinolylamine reacted easily with various aldehydes in the presence of aqueous ammonia to afford mainly trifluoromethylated pyrimido[5,4-c]quinoline derivatives in moderate to high yields. In contrast, the use of ketones instead of aldehydes in the presence of pyrrolidine, exclusively gave benzo[h][1,6]naphthyridine derivatives in good to excellent yields.

引用

页码：102 / 116

页数：15

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