Convenient and Clean Synthesis of Isatins by Metal-Free Oxidation of Oxindoles

被引：15
作者：
Wei, Wen-Ting [1 ]
Ying, Wei-Wei [1 ]
Zhu, Wen-Ming [1 ]
Wu, Yi [1 ]
Huang, Yi-Ling [1 ]
Cao, Yi-Qi [1 ]
Wang, Yi-Ning [1 ]
Liang, Hongze [1 ]
机构：
[1] Ningbo Univ, Sch Mat Sci & Chem Engn, Ningbo 315211, Zhejiang, Peoples R China
来源：
SYNLETT | 2017年 / 28卷 / 17期
关键词：
oxidation; oxindoles; butyl nitrite; isatins; metal-free synthesis; TERT-BUTYL NITRITE; NITRATIVE CYCLIZATION; MOLECULAR-OXYGEN; IONIC LIQUID; ACCESS; DERIVATIVES; OXIDANT; BOND;
D O I：
10.1055/s-0036-1590965
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A metal-free synthesis of isatins was achieved through the oxidative reactions of oxindoles with molecular oxygen in the presence of tert-butyl nitrite as an additive. This strategy provides a convenient and simple synthetic route to the construction of C= O bonds without the need for any catalyst or base. The attractive features of this reaction include its convenient procedure and mild reaction conditions.
引用
收藏
页码：2307 / 2310
页数：4
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