Intra-observer and inter-observer agreements for the measurement of dual-input whole tumor computed tomography perfusion in patients with lung cancer: Influences of the size and inner-air density of tumors

被引:2
作者
Wang, Qingle [1 ,2 ,3 ]
Zhang, Zhiyong [1 ,2 ,3 ]
Shan, Fei [2 ,3 ,4 ]
Shi, Yuxin [2 ,3 ,4 ]
Xing, Wei [5 ]
Shi, Liangrong [6 ]
Zhang, Xingwei [1 ,2 ,3 ]
机构
[1] Fudan Univ, Zhongshan Hosp, Dept Radiol, Shanghai, Peoples R China
[2] Shanghai Inst Med Imaging, Shanghai, Peoples R China
[3] Fudan Univ, Shanghai Med Coll, Dept Med Imaging, Shanghai, Peoples R China
[4] Fudan Univ, Shanghai Publ Hlth Clin Ctr, Dept Radiol, 2901 Caolang Rd, Shanghai 201508, Peoples R China
[5] Suzhou Univ, Dept Radiol, Affiliated Hosp 3, Suzhou, Peoples R China
[6] Suzhou Univ, Dept Oncol, Affiliated Hosp 3, Suzhou, Peoples R China
基金
中国国家自然科学基金;
关键词
CT perfusion; dual-blood supply; lung cancer; observer variation; SOLITARY PULMONARY NODULES; AREA-DETECTOR CT; DIFFERENTIATION; PREDICTION; MANAGEMENT;
D O I
10.1111/1759-7714.12458
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BackgroundThis study was conducted to assess intra-observer and inter-observer agreements for the measurement of dual-input whole tumor computed tomography perfusion (DCTP) in patients with lung cancer. MethodsA total of 88 patients who had undergone DCTP, which had proved a diagnosis of primary lung cancer, were divided into two groups: (i) nodules (diameter 3cm) and masses (diameter >3cm) by size, and (ii) tumors with and without air density. Pulmonary flow, bronchial flow, and pulmonary index were measured in each group. Intra-observer and inter-observer agreements for measurement were assessed using intraclass correlation coefficient, within-subject coefficient of variation, and Bland-Altman analysis. ResultsIn all lung cancers, the reproducibility coefficient for intra-observer agreement (range 26.1-38.3%) was superior to inter-observer agreement (range 38.1-81.2%). Further analysis revealed lower agreements for nodules compared to masses. Additionally, inner-air density reduced both agreements for lung cancer. ConclusionThe intra-observer agreement for measuring lung cancer DCTP was satisfied, while the inter-observer agreement was limited. The effects of tumoral size and inner-air density to agreements, especially between two observers, should be emphasized. In future, an automatic computer-aided segment of perfusion value of the tumor should be developed.
引用
收藏
页码:427 / 435
页数:9
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