Allogeneic hematopoietic cell transplantation for adult patients with treatment-related acute myeloid leukemia during first remission: Comparable to de novo acute myeloid leukemia

被引：6

作者：

Tang, Fei-Fei ^{[1
]}

Huang, Xiao-Jun ^{[1
,2
,3
]}

Zhang, Xiao-Hui ^{[1
]}

Chen, Huan ^{[1
]}

Chen, Yu-Hong ^{[1
]}

Han, Wei ^{[1
]}

Chen, Yao ^{[1
]}

Wang, Feng-Rong ^{[1
]}

Wang, Yu ^{[1
]}

Wang, Jing-Zhi ^{[1
]}

Yan, Chen-Hua ^{[1
]}

Sun, Yu-Qian ^{[1
]}

Mo, Xiao-Dong ^{[1
]}

Liu, Kai-Yan ^{[1
]}

Xu, Lan-Ping ^{[1
]}

机构：

[1] Peking Univ, Inst Hematol, Peoples Hosp, 11 Xizhimen South St, Beijing 100044, Peoples R China

[2] Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China

[3] Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing, Peoples R China

来源：

LEUKEMIA RESEARCH | 2016年 / 47卷

基金：

中国国家自然科学基金;

关键词：

Acute myeloid leukemia; Allogeneic hematopoietic cell transplantation; Therapy-related; MYELODYSPLASTIC SYNDROME; SECONDARY; THERAPY; AML; CHEMOTHERAPY; GRAFT;

D O I：

10.1016/j.leukres.2016.05.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Therapy-related acute myeloid leukemia (T-AML) is associated with poor prognosis after conventional therapy. Allogeneic hematopoietic cell transplantation (allo-HCT) has been proposed as a treatment for T-AML; however, data comparing outcomes of transplants for patients with de novo AML and T-AML are limited. Sixteen adult patients with T-AML during first complete remission after malignant disease received allo-HCT at the Peking University Institute of Hematology between January 1, 2006 and December 31, 2014. Eighty patients with de novo AML were selected using the case-pair method. The 3-year overall survival and leukemia-free survival for T-AML versus de novo AML patients were 66% vs. 79% (P=0.14) and 64% vs. 77% (P=0.13), respectively. The 3-year cumulative non-relapse mortality rates for T-AML versus de novo AML patients were 13% vs. 9% (P=0.47), respectively; the relapse rates were 20% vs. 13% (P=0.25), respectively. Our results suggest that the prognosis of T-AML is comparable to that of de novo AML after transplantation. Although T-AML shows poorer prognosis than de novo AML after conventional therapies, allo-HCT can markedly improve the prognosis of T-AML. (C) 2016. Published by Elsevier Ltd.

引用

页码：8 / 15

页数：8

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