Studies of in vitro Evaluation and Formulation of Aceclofenac Loaded PLGA Microspheres

The aim of this research was to study the influence of formulation parameters in the preparation of sustained release aceclofenac loaded PLGA microspheres by emulsion solvent diffusion technique. The methods used in this components and their concentration necessary for organogels formation were evaluated using phase diagram Solubility of aceclofenac was determined, Characterization of Poly (DL-lactide)-co-glycolide (PLGA) polymer, solubility assessment of aceclofenac, drug-excipients compatibility studies, in vitro analytical method development, preparation of aceclofenac-loaded PLGA microspheres, characterization of the formulations. Prepared microspheres were optimized and evaluated for different parameters and best formulation was subjected to in vitro drug release studies. The prepared microspheres were white, free-flowing and almost spherical in shape. In vitro drug release studies were carried out up to 24 h in three different pH media, i.e., 0.1 N HCl (pH 1.2), phosphate buffer (pH 6.8) and phosphate buffer (pH 7.4). The drug-polymer concentration of dispersed phase influences the particle size and drug release properties. In nut shell it may be concluded that sustained release aceclofenac microspheres can be successfully prepared and used parenterally with increased therapeutic value and reduced side effects.