An Overview of Concepts for Cancer Stem Cells

被引：28

作者：

Chen, Shih-Yin ^{[2
,3
]}

Huang, Yu-Chuen ^{[2
,3
]}

Liu, Shih-Ping ^{[1
,4
]}

Tsai, Fuu-Jen ^{[2
,5
]}

Shyu, Woei-Cherng ^{[1
]}

Lin, Shinn-Zong ^{[1
,6
]}

机构：

[1] China Med Univ & Hosp, Ctr Neuropsychiat, Taichung, Taiwan

[2] China Med Univ Hosp, Dept Med Res, Genet Ctr, Taichung, Taiwan

[3] China Med Univ, Grad Inst Chinese Med Sci, Coll Chinese Med, Taichung, Taiwan

[4] China Med Univ, Grad Inst Basic Med Sci, Taichung, Taiwan

[5] Asia Univ, Dept Biotechnol & Bioinformat, Taichung, Taiwan

[6] China Med Univ Beigang Hosp, Yunlin, Taiwan

来源：

CELL TRANSPLANTATION | 2011年 / 20卷 / 01期

关键词：

Cancer stem cell (CSC); Adult stem cells; Tumor-initiating cells; Self-renewal; ACUTE MYELOID-LEUKEMIA; HEMATOPOIETIC STEM; ALDEHYDE DEHYDROGENASE; PROSPECTIVE IDENTIFICATION; GEMTUZUMAB OZOGAMICIN; PROGENITOR CELLS; SELF-RENEWAL; EXPRESSION; SUBPOPULATION; BIOLOGY;

D O I：

10.3727/096368910X532837

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

For many years, cancer research has focused on the adult stem cells present in malignant tumors. It is believed that current cancer treatments sometimes fail because they do not target these cells. According to classic models of carcinogenesis, these events can occur in any cell. In contrast, the cancer stem cell (CSC) hypothesis states that the preferential targets of oncogenic transformation are tissue stem cells or early progenitor cells that have acquired the potential for self-renewal. These tumor-initiating cells, or CSCs, in turn, are characterized by their ability to undergo self-renewal, a process that drives tumorigenesis and differentiation, which contributes to the cellular heterogeneity of tumors. Herein, we discuss the definitions and properties of CSCs in the major human cancers.

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页码：113 / 120

页数：8

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