Palladium-Catalyzed Four-Component Carbonylative Cyclization Reaction of Trifluoroacetimidoyl Chlorides, Propargyl Amines, and Diaryliodonium Salts: Access to Trifluoromethyl-Containing Trisubstituted Imidazoles

被引：48

作者：

Chen, Zhengkai ^{[1
]}

Wang, Wei-Feng ^{[1
]}

Yang, Hefei ^{[1
]}

Wu, Xiao-Feng ^{[1
,2
]}

机构：

[1] Zhejiang Sci Tech Univ, Dept Chem, Hangzhou 310018, Peoples R China

[2] Univ Rostock, Leibniz Inst Katalyse eV, D-18059 Rostock, Germany

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 05期

基金：

中国国家自然科学基金;

关键词：

EFFICIENT SYNTHESIS; ARYL HALIDES; ISOCYANIDES; FLUORINE; FUNCTIONALIZATION; ALKYNYLATION; CHEMISTRY; IMINES;

D O I：

10.1021/acs.orglett.0c00328

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A palladium-catalyzed four-component carbonylative cyclization reaction for the expeditious construction of trifluoromethyl-containing trisubstituted imidazoles has been achieved. With readily accessible trifluoroacetimidoyl chlorides, propargyl amines, and diaryliodonium salts as the starting materials, the carbonylative transformation proceeds smoothly under mild conditions to enable the formation of multifunctionalized imidazole molecules in a one-pot, one-step manner. Diaryliodonium salts serve as both oxidants and aryl sources in the reaction.

引用

页码：1980 / 1984

页数：5

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