Motor impairment in Alzheimer's disease and transgenic Alzheimer's disease mouse models

被引：44

作者：

Wirths, O. ^{[1
]}

Bayer, T. A. ^{[1
]}

机构：

[1] Univ Gottingen, Dept Psychiat, Div Mol Psychiat, D-37075 Gottingen, Germany

来源：

GENES BRAIN AND BEHAVIOR | 2008年 / 7卷

关键词：

Alzheimer's disease; amyloid; APP; axonal transport; intracellular A beta; motor impairment; tau;

D O I：

10.1111/j.1601-183X.2007.00373.x

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

In this commentary, we accent the accumulating evidence for motor impairment as a common feature of early Alzheimer's disease (AD) pathology. In addition, we summarize the state of knowledge on this phenotype in experimental mouse models, expressing AD-associated genes like tau or amyloid precursor protein.

引用

页码：1 / 5

页数：5

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