Macromolecular agents with antimicrobial potentialities: A drive to combat antimicrobial resistance

被引：26

作者：

Bilal, Muhammad ^{[1
,2
]}

Rasheed, Tahir ^{[3
]}

Iqbal, Hafiz M. N. ^{[4
]}

Hu, Hongbo ^{[1
,2
]}

Wang, Wei ^{[1
,2
]}

Zhang, Xuehong ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, State Key Lab Microbial Metab, Shanghai 200240, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, State Key Lab Met Matrix Composites, Shanghai 200240, Peoples R China

[4] Tecnol Monterrey, Sch Engn & Sci, Campus Monterrey,Ave Eugenio Garza Sada 2501, Monterrey 64849, NL, Mexico

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2017年 / 103卷

关键词：

Antimicrobial resistance; Plant-derived antimicrobial; Metal-based antimicrobial; Macromolecules; Nanotechnology-assisted antimicrobials; INFECTIOUS-DISEASES-SOCIETY; ANTIBACTERIAL ACTIVITY; SILVER NANOPARTICLES; ESCHERICHIA-COLI; CHEMICAL-COMPOSITION; MEDICINAL-PLANTS; ESSENTIAL OILS; STAPHYLOCOCCUS-AUREUS; REACTIVE OXYGEN; PHYTOCHEMICAL CONSTITUENTS;

D O I：

10.1016/j.ijbiomac.2017.05.071

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In recent years, the antimicrobial resistance (AMR) or multidrug resistance (MDR) has become a serious health concern and major challenging issue, worldwide. After decades of negligence, the AMR has now captured global attention. The increasing number of antibiotic-resistant strains has threatened the achievements of science and medicine since it inactivates conventional antimicrobial therapeutics. Scientists are trying to respond to AMR/MDR threat by exploring innovative platforms and new therapeutic strategies to tackle infections from these resistant strains and bypass treatment limitations related to these pathologies. The present review focuses on the utilization of bio-inspired novel constructs and their potential applications as novel antimicrobial agents. The first part of the review describes plant based biological macromolecules containing an immense variety of secondary metabolites, which could be potentially used as alternative strategies to combat antimicrobial resistance. The second part discusses the potential of metal-based macromolecules as effective antimicrobial platforms for preventing infections from resistant strains. The third part comprehensively elucidates how nanoparticles, in particular, metal-integrated nanoparticles can overcome this AMR or MDR issue. Towards the end, information is given with critical concluding remarks, gaps, and finally envisioned with future considerations. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：554 / 574

页数：21

共 146 条

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