Mechanisms of Hepatoprotective Effect of Immobilized Granulocyte Colony-Stimulating Factor

被引：1

作者：

Dygai, A. M. ^{[1
]}

Zhdanov, V. V. ^{[1
]}

Zyuz'kov, G. N. ^{[1
]}

Stavrova, L. A. ^{[1
]}

Simanina, E. V. ^{[1
]}

Udut, E. V. ^{[1
]}

Khrichkova, T. Yu. ^{[1
]}

Miroshnichenko, L. A. ^{[1
]}

Vereshchagin, E. I. ^{[2
]}

Madonov, P. G. ^{[2
]}

Kinsht, D. N. ^{[2
]}

Fomina, T. I. ^{[1
]}

Vetoshkina, T. V. ^{[1
]}

Dubskaya, T. Yu. ^{[1
]}

Ermolaeva, L. A. ^{[1
]}

机构：

[1] Russian Acad Med Sci, Inst Pharmacol, Siberian Div, Tomsk, Russia

[2] Sci Features Management Co, Tomsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2011年 / 150卷 / 04期

关键词：

chronic hepatitis; granulocyte colony-stimulating factor; cell therapy;

D O I：

10.1007/s10517-011-1152-z

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effect of immobilized granulocyte CSF on morphological characteristics and functional state of the liver was studied during chronic toxic hepatitis. The mechanisms of the therapeutic action of this agent were evaluated. The product had a strong hepatoprotective effect and exhibited the antiinflammatory and antisclerotic properties. The mechanism of activation of reserve systems for cell renewal (involved in restoration of the liver tissue) is probably related to an increase in proliferative activity of early precursor cells in the bone marrow, mobilization of these cells into the peripheral circulation, and directed homing into the liver tissue where they activate local regenerative mechanisms and prevent hepatocyte destruction. It should be emphasized that the concentration of SDF-1 increases in the liver tissue, but decreases in the bone marrow. These changes create the concentration gradient, which determines the migration of undifferentiated precursor cells to the liver.

引用

页码：401 / 405

页数：5

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