Cyclodextrins in Drug Delivery Systems and Their Effects on Biological Barriers

被引：105

作者：

Haimhoffer, Adam ^{[1
,2
]}

Rusznyak, Agnes ^{[1
,2
]}

Reti-Nagy, Katalin ^{[1
]}

Vasvari, Gabor ^{[1
,2
]}

Varadi, Judit ^{[1
]}

Vecsernyes, Miklos ^{[1
]}

Bacskay, Ildiko ^{[1
]}

Feher, Palma ^{[1
]}

Ujhelyi, Zoltan ^{[1
]}

Fenyvesi, Ferenc ^{[1
]}

机构：

[1] Univ Debrecen, Fac Pharm, Dept Pharmaceut Technol, Nagyerdei St 98, H-4032 Debrecen, Hungary

[2] Univ Debrecen, Doctoral Sch Pharmaceut Sci, H-4032 Debrecen, Hungary

来源：

SCIENTIA PHARMACEUTICA | 2019年 / 87卷 / 04期

关键词：

cyclodextrins; drug delivery systems; biological barriers; nanopharmaceutics; NIEMANN-PICK-DISEASE; HOST-GUEST INTERACTION; BETA-CYCLODEXTRIN; ALPHA-CYCLODEXTRIN; IN-VITRO; P-GLYCOPROTEIN; AMPHIPHILIC CYCLODEXTRINS; MUCOADHESIVE EXCIPIENT; POLY(ETHYLENE GLYCOL); GAMMA-CYCLODEXTRINS;

D O I：

10.3390/scipharm87040033

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cyclodextrins are widely used excipients, composed of glucopyranose units with a cyclic structure. One of their most important properties, is that their inner cavity is hydrophobic, while their surface is hydrophilic. This enables them for the complex formation with lipophilic molecules. They have several applications in the pharmaceutical field like solubility enhancers or the building blocks of larger drug delivery systems. On the other hand, they have numerous effects on cells or biological barriers. In this review the most important properties of cyclodextrins and cyclodextrin-based drug delivery systems are summarized with special focus on their biological activity.

引用

页数：21

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