Apolipoprotein E: A cholesterol transport protein with lipid transport-independent cell signaling properties

被引：28

作者：

Swertfeger, DK ^{[1
]}

Hui, DY ^{[1
]}

机构：

[1] Univ Cincinnati, Coll Med, Dept Pathol & Lab Med, Cincinnati, OH 45267 USA

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2001年 / 6卷

关键词：

apolipoprotein; atherosclerosis; Alzheimer's disease; signal transduction; review;

D O I：

10.2741/Swertfeg

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Apolipoprotein (apo) E is a 34-kDa glycoprotein associated with plasma lipoproteins. In contrast to other apolipoproteins, apoE is expressed ubiquitously in all tissues and appears to have a wide variety of functions in addition to lipid transport. Although the lipid transport properties of apoE are well characterized, the appreciation apoE functions other than lipid transport is still in an infancy stage. Nevertheless, there is increasing evidence that apoE regulates cell functions in a variety of tissues and organs. This review article summarizes briefly the current status of our understanding on the lipid transport-independent properties of this apolipoprotein.

引用

页码：D526 / D535

页数：10

共 79 条

[21] Expression of human apolipoprotein E reduces amyloid-β deposition in a mouse model of Alzheimer's disease [J].

Holtzman, DM ;

Bales, KR ;

Wu, S ;

Bhat, P ;

Parsadanian, M ;

Fagan, AM ;

Chang, LK ;

Sun, YL ;

Paul, SM .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (06) :R15-R21

[22] Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease [J].

Holtzman, DM ;

Bales, KR ;

Tenkova, T ;

Fagan, AM ;

Parsadanian, M ;

Sartorius, LJ ;

Mackey, B ;

Olney, J ;

McKeel, D ;

Wozniak, D ;

Paul, SM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (06) :2892-2897

[23]

Howell BW, 1999, MOL CELL BIOL, V19, P5179

[24]

HUI DY, 1980, J BIOL CHEM, V255, P1775

[25] INHIBITION OF CA-2+ ACCUMULATION IN MITOGEN-ACTIVATED LYMPHOCYTES - ROLE OF MEMBRANE-BOUND PLASMA-LIPOPROTEINS [J].

HUI, DY ;

HARMONY, JAK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (08) :4764-4768

[26] PHOSPHATIDYLINOSITOL TURNOVER IN MITOGEN-ACTIVATED LYMPHOCYTES - SUPPRESSION BY LOW-DENSITY LIPOPROTEINS [J].

HUI, DY ;

HARMONY, JAK .

BIOCHEMICAL JOURNAL, 1980, 192 (01) :91-98

[27] LIPOPROTEIN UPTAKE BY NEURONAL GROWTH CONES INVITRO [J].

IGNATIUS, MJ ;

SHOOTER, EM ;

PITAS, RE ;

MAHLEY, RW .

SCIENCE, 1987, 236 (4804) :959-962

[28] Apolipoprotein E inhibition of vascular smooth muscle cell proliferation but not the inhibition of migration is mediated through activation of inducible nitric oxide synthase [J].

Ishigami, M ;

Swertfeger, DK ;

Hui, MS ;

Granholm, NA ;

Hui, DY .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2000, 20 (04) :1020-1026

[29] Apolipoprotein E inhibits platelet-derived growth factor-induced vascular smooth muscle cell migration and proliferation by suppressing signal transduction and preventing cell entry to G1 phase [J].

Ishigami, M ;

Swertfeger, DK ;

Granholm, NA ;

Hui, DY .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (32) :20156-20161

[30] APOLIPOPROTEIN-E DEFICIENCY IN MICE - GENE REPLACEMENT AND PREVENTION OF ATHEROSCLEROSIS USING ADENOVIRUS VECTORS [J].

KASHYAP, VS ;

SANTAMARINAFOJO, S ;

BROWN, DR ;

PARROTT, CL ;

APPLEBAUMBOWDEN, D ;

MEYN, S ;

TALLEY, G ;

PAIGEN, B ;

MAEDA, N ;

BREWER, HB .

JOURNAL OF CLINICAL INVESTIGATION, 1995, 96 (03) :1612-1620

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