The stability of pseudopeptides bearing sulfoximines as chiral backbone modifying element towards proteinase K

被引：51

作者：

Bolm, C ^{[1
]}

Müller, D ^{[1
]}

Dalhoff, C ^{[1
]}

Hackenberger, CPR ^{[1
]}

Weinhold, E ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52056 Aachen, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 19期

关键词：

D O I：

10.1016/S0960-894X(03)00697-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Incorporation of sulfoximines as backbone modifying element results in two new pseudopeptide bonds which display enhanced (bond A) and strongly reduced reactivity (bond B) towards hydrolysis by Proteinase K. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：3207 / 3211

页数：5

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