Corticotropin-releasing factor signaling and visceral response to stress

被引：118

作者：

Stengel, Andreas

Tache, Yvette ^{[1
]}

机构：

[1] VA Greater Los Angeles Healthcare Syst, CURE Digest Dis Res Ctr, Ctr Neurobiol Stress, Los Angeles, CA 90073 USA

来源：

EXPERIMENTAL BIOLOGY AND MEDICINE | 2010年 / 235卷 / 10期

关键词：

cardiovascular system; corticotropin-releasing factor (CRF); irritable bowel syndrome (IBS); stress; urocortin (Ucn); CENTRAL-NERVOUS-SYSTEM; MESSENGER-RNA EXPRESSION; FUNCTIONAL GASTROINTESTINAL DISORDERS; HORMONE-RECEPTOR ANTAGONIST; IRRITABLE-BOWEL-SYNDROME; WATER-AVOIDANCE STRESS; COLONIC MOTOR RESPONSE; FACTOR CRF RECEPTOR; UROCORTIN-II; PARAVENTRICULAR NUCLEUS;

D O I：

10.1258/ebm.2010.009347

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Stress may cause behavioral and/or psychiatric manifestations such as anxiety and depression and also impact on the function of different visceral organs, namely the gastrointestinal and cardiovascular systems. During the past years substantial progress has been made in the understanding of the underlying mechanisms recruited by stressors. Activation of the corticotropin-releasing factor (CRF) signaling system is recognized to be involved in a large number of stress-related behavioral and somatic disorders. This review will outline the present knowledge on the distribution of the CRF system (ligands and receptors) expressed in the brain and peripheral viscera and its relevance in stress-induced alterations of gastrointestinal and cardiovascular functions and the therapeutic potential of CRF1 receptor antagonists.

引用

页码：1168 / 1178

页数：11

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