Dopamine and serotonin transporter availability in chronic heroin users: A [123I]β-CIT SPECT imaging study

被引：22
作者：
Cosgrove, Kelly P. [1 ,2 ]
Tellez-Jacques, Karen [1 ,2 ]
Pittman, Brian [1 ,2 ]
Petrakis, Ismene [1 ,2 ]
Baldwin, Ronald M. [1 ,2 ]
Tamagnan, Gilles [3 ]
Seibyl, John [3 ]
Kosten, Thomas [4 ]
Staley, Julie K. [1 ,2 ]
机构：
[1] Yale Univ, Sch Med, New Haven, CT USA
[2] VACHS, New Haven, CT USA
[3] Inst Neurodegenerat Disorders, New Haven, CT USA
[4] Baylor Coll Med, Houston, TX 77030 USA
来源：
PSYCHIATRY RESEARCH-NEUROIMAGING | 2010年 / 184卷 / 03期
关键词：
Substance abuse; Single photon emission computed tomography (SPECT); Dopamine transporter; Serotonin transporter; I-123; BETA-CIT; CHRONIC MORPHINE TREATMENT; H-3 PAROXETINE BINDING; HUMAN-BRAIN; NONHUMAN-PRIMATES; UPTAKE SITES; ADDICTION; RAT; REPRODUCIBILITY; ASSOCIATION;
D O I：
10.1016/j.pscychresns.2010.08.001
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Dopamine (DA) and serotonin (5-HT) transporter availability in heroin users and healthy controls was measured using [I-123]beta-CIT and SPECT imaging. Heroin users had statistically similar striatal DA and brainstem and diencephalon 5-HT transporter availability compared with controls. No associations between transporter availability and heroin use characteristics were found. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：192 / 195
页数：4
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