Biomarkers in kidney and heart disease

被引：39

作者：

Maisel, Alan S. ^{[2
,3
]}

Katz, Nevin ^{[4
]}

Hillege, Hans L. ^{[5
]}

Shaw, Andrew ^{[6
]}

Zanco, Pierluigi ^{[7
]}

Bellomo, Rinaldo ^{[8
]}

Anand, Inder ^{[10
]}

Anker, Stefan D. ^{[11
,12
]}

Aspromonte, Nadia ^{[13
]}

Bagshaw, Sean M. ^{[14
]}

Berl, Tomas ^{[8
]}

Bobek, Ilona ^{[1
]}

Cruz, Dinna N. ^{[1
,9
]}

Daliento, Luciano ^{[15
]}

Davenport, Andrew ^{[16
]}

Haapio, Mikko ^{[18
]}

House, Andrew A. ^{[17
]}

Mankad, Sunil ^{[19
]}

McCullough, Peter ^{[10
,20
,21
]}

Mebazaa, Alexandre

Palazzuoli, Alberto ^{[22
]}

Ponikowski, Piotr ^{[23
]}

Ronco, Federico ^{[15
]}

Sheinfeld, Geoff ^{[24
]}

Soni, Sachin ^{[9
,25
]}

Vescovo, Giorgio ^{[26
]}

Zamperetti, Nereo ^{[27
]}

Ronco, Claudio ^{[1
]}

机构：

[1] St Bortolo Hosp, Dept Nephrol, Vicenza, Italy

[2] San Diego VA Med Ctr, Dept Med & Cardiol, San Diego, CA USA

[3] Univ Calif San Diego, San Diego, CA 92103 USA

[4] George Washington Univ, Dept Surg, Washington, DC USA

[5] Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol & Epidemiol, Trial Coordinat Ctr, Groningen, Netherlands

[6] Duke Univ, Med Ctr, Dept Anesthesiol, Durham, NC 27710 USA

[7] St Bortolo Hosp, Dept Imaging & Nucl Med, Vicenza, Italy

[8] Austin Hosp, Dept Intens Care, Melbourne, Vic 3084, Australia

[9] IRRIV, Vicenza, Italy

[10] William Beaumont Hosp, Dept Med Nutr & Prevent Med, Div Cardiol, Royal Oak, MI 48072 USA

[11] Campus Virchow Klinikum, Charite, Dept Cardiol, Berlin, Germany

[12] IRCCS San Raffaele, Ctr Clin & Basic Res, Rome, Italy

[13] St Spirito Hosp, Dept Cardiol, Rome, Italy

[14] Univ Alberta Hosp, Div Crit Care Med, Edmonton, AB T6G 2B7, Canada

[15] Univ Padua, Dept Cardiol, Padua, Italy

[16] Royal Free & Univ Coll Med Sch, UCL Ctr Nephrol, London WC1E 6BT, England

[17] Univ Western Ontario, Univ Hosp, London Hlth Sci Ctr, Div Nephrol, London, ON N6A 5A5, Canada

[18] Univ Helsinki, Cent Hosp, Div Nephrol, Helsinki, Finland

[19] Mayo Clin, Dept Cardiol, Rochester, MN USA

[20] Hop Lariboisiere, INSERM, U942, Dept Anesthesiol & Crit Care Med, Paris, France

[21] Univ Paris 07, Paris Diderot, France

[22] Univ Siena, Le Scotte Hosp, Dept Internal Med, I-53100 Siena, Italy

[23] Med Univ, Mil Hosp, Fac Publ Hlth, Dept Cardiac, Wroclaw, Poland

[24] Univ Maryland, Dept Crit Care, College Pk, MD 20742 USA

[25] Mediciti Hosp, Div Nephrol, Hyderabad, Andhra Pradesh, India

[26] San Bortolo Hosp, Dept Internal Med, Vicenza, Italy

[27] San Bortolo Hosp, Dept Intens Care, Vicenza, Italy

来源：

NEPHROLOGY DIALYSIS TRANSPLANTATION | 2011年 / 26卷 / 01期

关键词：

acute kidney injury; cardiorenal syndromes; chronic kidney disease; decompensated heart failure; GELATINASE-ASSOCIATED LIPOCALIN; BRAIN NATRIURETIC PEPTIDE; ACUTE-RENAL-FAILURE; EARLY URINARY BIOMARKER; BETA-D-GLUCOSAMINIDASE; CARDIAC TROPONIN-I; C-REACTIVE PROTEIN; PROGNOSTIC VALUE; TERMINAL PROBNP; GENE-EXPRESSION;

D O I：

10.1093/ndt/gfq647

中图分类号：

R3 [基础医学]; R4 [临床医学];

学科分类号：

1001 ; 1002 ; 100602 ;

摘要：

There is much symptomatic similarity between acute kidney disease and acute heart disease. Both may present with shortness of breath and chest discomfort, and thus it is not surprising that biomarkers of acute myocardial and renal disease often coexist in many physicians' diagnostic work-up schedules. In this review we explore the similarities and differences between current and future tests of myocardial and renal injury and function, with particular emphasis on the diagnostic utility of currently available biomarkers to assist with the diagnosis of cardiorenal syndromes. Imaging studies have not traditionally been viewed as clinical biomarkers, but as tests of structure and function; they contribute to the diagnostic process, and we believe that they should be considered alongside more traditional biomarkers such as blood and urine measurements of circulating proteins and metabolites. We discuss the place of natriuretic peptides, novel tests of kidney damage as well as kidney function and conclude with a discussion of their place in guiding future research studies whose goals must include better characterization of the degree of dysfunction imposed on one organ system by failure of the other.

引用

页码：62 / 74

页数：13

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