A facile approach to hydrophilic, reverse zwitterionic, choline phosphate polymers

被引：44

作者：

Hu, Gaojie ^{[1
]}

Parelkar, Sangram S. ^{[1
]}

Emrick, Todd ^{[1
]}

机构：

[1] Univ Massachusetts, Dept Polymer Sci & Engn, Amherst, MA 01003 USA

来源：

POLYMER CHEMISTRY | 2015年 / 6卷 / 04期

基金：

美国国家卫生研究院;

关键词：

PHOSPHATIDYLCHOLINE ANALOGOUS MOIETIES; UNIVERSAL BIOMEMBRANE ADHESIVE; POLY(2-METHACRYLOYLOXYETHYL PHOSPHORYLCHOLINE); PHOSPHOLIPID ANALOGS; PROTEIN CONJUGATION; POLYMERIZATION; BETAINES; BEARING; SPACER;

D O I：

10.1039/c4py01292e

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

2-{2-(Methacryloyloxy) ethyldimethylammonium}ethyl n-butyl phosphate (MBP) was synthesized and polymerized by controlled free radical methods to afford a new set of "reverse zwitterionic" choline phosphate (CP) substituted polymers. The synthesis overcomes prior limitations associated with related CP-methacrylates, affording facile access to MBP homopolymers and MBP-containing diblock copolymers. Dynamic light scattering revealed the size of polyMBP in water, while cell culture assays showed polyMBP to have excellent biocompatibility and non-immunogenicity. The facile synthesis of MBP monomer, and the corresponding polymers, opens a new platform towards a diverse set of functional, hydrophilic biocompatible polymers.

引用

页码：525 / 530

页数：6

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