A facile approach to hydrophilic, reverse zwitterionic, choline phosphate polymers

被引：42
作者：
Hu, Gaojie [1 ]
Parelkar, Sangram S. [1 ]
Emrick, Todd [1 ]
机构：
[1] Univ Massachusetts, Dept Polymer Sci & Engn, Amherst, MA 01003 USA
来源：
POLYMER CHEMISTRY | 2015年 / 6卷 / 04期
基金：
美国国家卫生研究院;
关键词：
PHOSPHATIDYLCHOLINE ANALOGOUS MOIETIES; UNIVERSAL BIOMEMBRANE ADHESIVE; POLY(2-METHACRYLOYLOXYETHYL PHOSPHORYLCHOLINE); PHOSPHOLIPID ANALOGS; PROTEIN CONJUGATION; POLYMERIZATION; BETAINES; BEARING; SPACER;
D O I：
10.1039/c4py01292e
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
2-{2-(Methacryloyloxy) ethyldimethylammonium}ethyl n-butyl phosphate (MBP) was synthesized and polymerized by controlled free radical methods to afford a new set of "reverse zwitterionic" choline phosphate (CP) substituted polymers. The synthesis overcomes prior limitations associated with related CP-methacrylates, affording facile access to MBP homopolymers and MBP-containing diblock copolymers. Dynamic light scattering revealed the size of polyMBP in water, while cell culture assays showed polyMBP to have excellent biocompatibility and non-immunogenicity. The facile synthesis of MBP monomer, and the corresponding polymers, opens a new platform towards a diverse set of functional, hydrophilic biocompatible polymers.
引用
收藏
页码：525 / 530
页数：6
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