Cyclooxygenase-2 in testes of infertile men: evidence for the induction of prostaglandin synthesis by interleukin-1β

被引：39

作者：

Eugenia Matzkin, Maria ^{[2
]}

Mayerhofer, Artur ^{[3
]}

Paola Rossi, Soledad

Gonzalez, Betina

Rocio Gonzalez, Candela

Ines Gonzalez-Calvar, Silvia ^{[2
]}

Terradas, Claudio ^{[4
]}

Ponzio, Roberto

Puigdomenech, Elisa

Levalle, Oscar ^{[4
]}

Saul Calandra, Ricardo

Beatriz Frungieri, Monica ^{[1
,2
]}

机构：

[1] Consejo Nacl Invest Cient & Tecn, Lab Esteroides, Inst Biol & Med Expt, CABA, RA-1428 Buenos Aires, DF, Argentina

[2] Univ Buenos Aires, Fac Med, Dept Bioquim Humana, Buenos Aires, DF, Argentina

[3] Univ Munich, Inst Zellbiol, Munich, Germany

[4] Univ Buenos Aires, Fac Med, Div Endocrinol, Hosp Durand, Buenos Aires, DF, Argentina

来源：

FERTILITY AND STERILITY | 2010年 / 94卷 / 05期

关键词：

HAMSTER LEYDIG-CELLS; EXPRESSION; SPERMATOGENESIS; RAT;

D O I：

10.1016/j.fertnstert.2010.01.039

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

As we previously reported, testes of men suffering from hypospermatogenesis and germ cell arrest or Sertoli cell-only syndrome show a major increase in the number of macrophages expressing interleukin-1 beta (IL-1 beta) and abundant expression of cyclooxygenase-2 (COX-2), the inducible isoform of the key enzyme in the biosynthesis of prostaglandins (PGs), in Leydig cells. In the present study we report [1] a positive correlation between IL-1b levels and COX-2 expression in testes of infertile patients, [2] the induction of COX-2 by IL-1b in mouse Leydig cells (TM3) and human macrophages (THP-1), and therefore [3] evidence for an IL-1 beta-dependent induction of testicular inflammatory states. (Fertil Steril (R) 2010;94:1933-6. (C) 2010 by American Society for Reproductive Medicine.)

引用

页码：1933 / 1936

页数：4

共 14 条

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