Reemergence of Chikungunya virus in Indian Subcontinent

被引:29
作者
Kumar, C. V. M. Naresh [1 ]
Gopal, D. V. R. Sai [1 ]
机构
[1] Sri Venkateswara Univ, Dept Virol, Coll Sci, Tirupati 517502, Andhra Pradesh, India
来源
INDIAN JOURNAL OF VIROLOGY | 2010年 / 21卷 / 01期
关键词
CHIKV; Aedes mosquito; Co-infection; Mutation; RT-PCR; Differential diagnosis; Vaccine; RT-PCR ASSAY; MOLECULAR CHARACTERIZATION; HEMORRHAGIC-FEVER; EPIDEMIC; OUTBREAK; INFECTION; TRANSMISSION; REPLICATION; DISEASE; QUANTIFICATION;
D O I
10.1007/s13337-010-0012-1
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Chikungunya virus (CHIKV), a reemerging arboviral disease of public health concern is characterized by a triad of fever, rash and arthralgia. It was responsible for a number of epidemics in Asia and Africa. The severity of the current epidemic can be judged by the fact that an estimated 1.38 million people in India and one-third of the La Reunion population (by April 2006) were affected by CHIKV. Aedes aegypti and Aedes albopictus are the major mosquitoes transmitting CHIKV in Asia. Various neurological complications and CHIKV associated deaths were encountered during the current outbreak (2005-2010). The aggressive nature of the recent CHIKV epidemic was attributed to the mutations in the viral genome in addition to their adaptation and spread to vectors like Aedes albopictus. Proper diet, adequate rest and symptomatic treatment using non-salicylate analgesics and Non-steroidal anti inflammatory drugs (NSAIDS) helped the patients in recovering from CHIKV infections. In the absence of an effective vaccine, rapid implementation of mosquito control measures and establishment of a system for continuous surveillance of the disease seems to be the only possible solution to prevent any such outbreak in the near future.
引用
收藏
页码:8 / 17
页数:10
相关论文
共 84 条
[1]   A virus-like particle vaccine for epidemic Chikungunya virus protects nonhuman primates against infection [J].
Akahata, Wataru ;
Yang, Zhi-Yong ;
Andersen, Hanne ;
Sun, Siyang ;
Holdaway, Heather A. ;
Kong, Wing-Pui ;
Lewis, Mark G. ;
Higgs, Stephen ;
Rossmann, Michael G. ;
Rao, Srinivas ;
Nabel, Gary J. .
NATURE MEDICINE, 2010, 16 (03) :334-U134
[2]   Genetic divergence of Chikungunya viruses in India (1963-2006) with special reference to the 2005-2006 explosive epidemic [J].
Arankalle, Vidya A. ;
Shrivastava, Shubham ;
Cherian, Sarah ;
Gunjikar, Rashmi S. ;
Walimbe, Atul M. ;
Jadhav, Santosh M. ;
Sudeep, A. B. ;
Mishra, Akhilesh C. .
JOURNAL OF GENERAL VIROLOGY, 2007, 88 :1967-1976
[3]  
BANERJEE K, 1965, INDIAN J MED RES, V53, P715
[4]   Chikungunya: an epidemic in real time [J].
Bodenmann, Patrick ;
Genton, Blaise .
LANCET, 2006, 368 (9531) :258-258
[5]  
BRIGHTON SW, 1984, S AFR MED J, V66, P217
[6]  
BRIGHTON SW, 1983, S AFR MED J, V63, P313
[7]   In vitro inhibition of Chikungunya and Semliki Forest viruses replication by antiviral compounds:: synergistic effect of interferon-α and ribavirin combination [J].
Briolant, S ;
Garin, D ;
Scaramozzino, N ;
Jouan, A ;
Crance, JM .
ANTIVIRAL RESEARCH, 2004, 61 (02) :111-117
[8]   Estimated risk of Chikungunya viremic blood donation during an epidemic on Reunion Island in the Indian Ocean, 2005 to 2007 [J].
Brouard, Cecile ;
Bernillon, Pascale ;
Quatresous, Isabelle ;
Pillonel, Josiane ;
Assal, Azzedine ;
De Valk, Henriette ;
Desenclos, Jean-Claude .
TRANSFUSION, 2008, 48 (07) :1333-1341
[9]  
CALISHER CH, 1999, ENCY VIROLOGY, V1, P261
[10]   Co-infections with Chikungunya Virus and Dengue Virus in Delhi, India [J].
Chahar, Harendra S. ;
Bharaj, Preeti ;
Dar, Lalit ;
Guleria, Randeep ;
Kabra, Sushill K. ;
Broor, Shobha .
EMERGING INFECTIOUS DISEASES, 2009, 15 (07) :1077-1080