Three-Component Bicyclization Leading to Densely Functionalized Pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidines

被引：8

作者：

Hao, Wen-Juan ^{[1
]}

Zhou, Peng ^{[1
]}

Wu, Fei-Yue ^{[1
]}

Jiang, Bo ^{[1
,2
]}

Tu, Shu-Jiang ^{[1
]}

Li, Guigen ^{[2
,3
]}

机构：

[1] Jiangsu Normal Univ, Sch Chem & Chem Engn, Xuzhou 221116, Jiangsu, Peoples R China

[2] Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79409 USA

[3] Nanjing Univ, Collaborat Innovat Ctr Chem Life Sci, Inst Chem & BioMed Sci, Nanjing 210093, Jiangsu, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 2016卷 / 11期

基金：

中国国家自然科学基金; 美国国家卫生研究院; 美国国家科学基金会;

关键词：

Multicomponent reactions; Microwave chemistry; Cyclization; Polycycles; Fused-ring systems; STEREOSELECTIVE-SYNTHESIS; MULTICOMPONENT REACTIONS; DOMINO REACTION; ACCESS; CONSTRUCTION; RITANSERIN; HETEROANNULATION; CYCLOADDITION; DERIVATIVES; PATHWAYS;

D O I：

10.1002/ejoc.201600163

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A three-component bicyclization strategy for the efficient synthesis of densely functionalized pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidines from readily accessible aryl aldehydes, -thiocyanate ketones, and pyrazol-5-amines was established. The reaction pathway involves a nucleophilic addition/5-exo-trig/6-endo-trig bicyclization sequence that results in continuous multiple bond-forming events, including the formation of C-N and C-C bonds, to give high levels of molecular complexity.

引用

页码：1968 / 1971

页数：4

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